about
The decision to enter mitosis: feedback and redundancy in the mitotic entry networkBuilding a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora AA TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridgingCoordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle bindingAdvances in targeted therapies and new promising targets in esophageal cancerCurrent and future trials of targeted therapies in cutaneous melanomaAurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle AssemblyAurora A drives early signalling and vesicle dynamics during T-cell activation.Timeless links replication termination to mitotic kinase activationMeiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytesOptimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid LeukemiaAurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionRole of cell cycle regulators in lung carcinogenesisMetastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cellsRole of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesisInhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cellsEfficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301Aurora kinase-A regulates microtubule organizing center (MTOC) localization, chromosome dynamics, and histone-H3 phosphorylation in mouse oocytesBora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosisAurora kinase-A deficiency during skin development impairs cell division and stratificationAurora A is essential for early embryonic development and tumor suppressionMitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosisSMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancersAllosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2Identification of Aurora-A Inhibitors by Ligand and Structure-Based Virtual Screening.MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics.A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular functionCoordination of glioblastoma cell motility by PKCιThe UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.Aurora A kinase and its substrate TACC3 are required for central spindle assemblyCdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.Phase I study of MLN8237--investigational Aurora A kinase inhibitor--in relapsed/refractory multiple myeloma, non-Hodgkin lymphoma and chronic lymphocytic leukemia.Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors.Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.Dimerization of CPAP orchestrates centrosome cohesion plasticity.Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest.CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response.Aurora A contributes to p150(glued) phosphorylation and function during mitosisQuantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Aurora-A: the maker and breaker of spindle poles.
@en
type
label
Aurora-A: the maker and breaker of spindle poles.
@en
prefLabel
Aurora-A: the maker and breaker of spindle poles.
@en
P356
P1476
Aurora-A: the maker and breaker of spindle poles.
@en
P304
P356
10.1242/JCS.013136
P407
P577
2007-09-01T00:00:00Z