Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. - Test2 - elhamkhani - TriplyDB

Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid.

Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid.

http://www.wikidata.org/entity/Q36952136

about

pH sensing and regulation in cancer Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions Cancer: fundamentals behind pH targeting and the double-edged approach Tissue-specific expression of monocarboxylate transporters during fasting in mice.Regulation of ion channels and transporters by AMP-activated kinase (AMPK).The Concise Guide to PHARMACOLOGY 2013/14: transporters.Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells Role of monocarboxylate transporters in drug delivery to the brain.Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines.Quantitative structure-pharmacokinetic relationships for the prediction of renal clearance in humans Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid.SCFA transport in rat duodenum.Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation.Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS Prognostic significance of monocarboxylate transporter 4 expression in patients with colorectal cancer.Anticancer agents that counteract tumor glycolysis.Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells.MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.Brain extracellular γ-hydroxybutyrate concentrations are decreased by L-lactate in rats: role in the treatment of overdoses Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device.Molecular identification and characterization of an essential pyruvate transporter from Trypanosoma brucei.LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans.The role of bacterial vaginosis and trichomonas in HIV transmission across the female genital tract.Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention.Drug interactions at the blood-brain barrier: fact or fantasy?Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells Butyrate utilization by the colonic mucosa in inflammatory bowel diseases: a transport deficiency.Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery.The role of blood-ocular barrier transporters in retinal drug disposition: an overview.Nanostructure-based drug delivery systems for brain targeting.Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier.Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.Proton production, regulation and pathophysiological roles in the mammalian brain Roles of ion transport in control of cell motility.Intestinal transporters: enhanced absorption through P-glycoprotein-related drug interactions.

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P2860

Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid.

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Overview of the proton-coupled ...... use gamma-hydroxybutyric acid.

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Overview of the proton-coupled ...... use gamma-hydroxybutyric acid.

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Marilyn E Morris

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Melanie A Felmlee

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P2860

Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function

Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past

The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

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