Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.
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Discovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes.Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog FoldC-S bond cleavage by a polyketide synthase domain.Decoding and reprogramming fungal iterative nonribosomal peptide synthetases.Genetic transformation of Diaporthe phaseolorum, an endophytic fungus found in mangrove forests, mediated by Agrobacterium tumefaciens.Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen speciesCharacterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis.Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthaseSynthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.Type I polyketide synthases that require discrete acyltransferases.Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine.Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis.Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics.Pyxipyrrolones: Structure Elucidation and Biosynthesis of Cytotoxic Myxobacterial Metabolites.Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis.Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A.
P2860
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P2860
Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Polyketide chain skipping mech ...... eptomyces atroolivaceus S-140.
@en
type
label
Polyketide chain skipping mech ...... eptomyces atroolivaceus S-140.
@en
prefLabel
Polyketide chain skipping mech ...... eptomyces atroolivaceus S-140.
@en
P2093
P2860
P356
P1476
Polyketide chain skipping mech ...... eptomyces atroolivaceus S-140.
@en
P2093
Gong-Li Tang
Yi-Qiang Cheng
P2860
P304
P356
10.1021/NP050467T
P577
2006-03-01T00:00:00Z