Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. - Test2 - elhamkhani - TriplyDB

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

http://www.wikidata.org/entity/Q30650504

about

Genome-scale engineering for systems and synthetic biology Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891 StreptomeDB: a resource for natural compounds isolated from Streptomyces species Principles of microbial alchemy: insights from the Streptomyces coelicolor genome sequence Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase Mechanistic Insights into Validoxylamine A 7'-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis Combinatorial biosynthesis of polyketides--a perspective.A multiplasmid approach to preparing large libraries of polyketides.Production of cyclic peptides and proteins in vivo Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489 The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides.Combinatorial biosynthesis--potential and problems.ASMPKS: an analysis system for modular polyketide synthases Engineered production of iso-migrastatin in heterologous Streptomyces hosts.Microbial polyketide synthases: more and more prolific.Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.Novel macrolides through genetic engineering.Metabolic engineering for the production of natural products.The evolution of secondary metabolism - a unifying model.Biosynthesis of polyketides in heterologous hosts Roles of type II thioesterases and their application for secondary metabolite yield improvement.Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.Fungal polyketide engineering comes of age.Engineering synthetic recursive pathways to generate non-natural small molecules.Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host.Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains.DNA assembly techniques for next-generation combinatorial biosynthesis of natural products.Recent developments in the production of novel polyketides by combinatorial biosynthesis.Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units.Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system The enzymology of combinatorial biosynthesis.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.A key cytochrome P450 hydroxylase in pradimicin biosynthesis.Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities.

P2860

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P2860

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

http://www.wikidata.org/entity/Q30650504

description

1999 nî lūn-bûn

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1999 թուականի Մարտին հրատարակուած գիտական յօդուած

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1999 թվականի մարտին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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Multiple genetic modifications ...... "unnatural" natural products.

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Multiple genetic modifications ...... l "unnatural" natural products

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P2093

G Ashley

http://www.w3.org/2001/XMLSchema#string

H Fu

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M Betlach

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R McDaniel

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P2860

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

The expanded horizon for microbial metabolites--a review.

An erythromycin analog produced by reprogramming of polyketide synthesis.

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

Engineered biosynthesis of a complete macrolactone in a heterologous host.

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.

Engineered biosynthesis of novel polyketides.

Modular organization of genes required for complex polyketide biosynthesis.

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea.

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits.

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1846-1851

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scholarly article

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10.1073/PNAS.96.5.1846

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5

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96

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Claes Gustafsson

Arinthip Thamchaipenet

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13237905

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26699

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