Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.
about
Genome-scale engineering for systems and synthetic biologyIdentification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891StreptomeDB: a resource for natural compounds isolated from Streptomyces speciesPrinciples of microbial alchemy: insights from the Streptomyces coelicolor genome sequenceCrystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesisCrystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channelSolution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthaseMechanistic Insights into Validoxylamine A 7'-Phosphate Synthesis by VldE Using the Structure of the Entire Product ComplexNatural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilisCombinatorial biosynthesis of polyketides--a perspective.A multiplasmid approach to preparing large libraries of polyketides.Production of cyclic peptides and proteins in vivoIdentification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides.Combinatorial biosynthesis--potential and problems.ASMPKS: an analysis system for modular polyketide synthasesEngineered production of iso-migrastatin in heterologous Streptomyces hosts.Microbial polyketide synthases: more and more prolific.Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.Novel macrolides through genetic engineering.Metabolic engineering for the production of natural products.The evolution of secondary metabolism - a unifying model.Biosynthesis of polyketides in heterologous hostsRoles of type II thioesterases and their application for secondary metabolite yield improvement.Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.Fungal polyketide engineering comes of age.Engineering synthetic recursive pathways to generate non-natural small molecules.Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host.Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains.DNA assembly techniques for next-generation combinatorial biosynthesis of natural products.Recent developments in the production of novel polyketides by combinatorial biosynthesis.Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units.Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 systemThe enzymology of combinatorial biosynthesis.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.A key cytochrome P450 hydroxylase in pradimicin biosynthesis.Evolution of Efficient Modular Polyketide Synthases by Homologous RecombinationGene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities.
P2860
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P2860
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Multiple genetic modifications ...... "unnatural" natural products.
@ast
Multiple genetic modifications ...... "unnatural" natural products.
@en
type
label
Multiple genetic modifications ...... "unnatural" natural products.
@ast
Multiple genetic modifications ...... "unnatural" natural products.
@en
prefLabel
Multiple genetic modifications ...... "unnatural" natural products.
@ast
Multiple genetic modifications ...... "unnatural" natural products.
@en
P2093
P2860
P356
P1476
Multiple genetic modifications ...... l "unnatural" natural products
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.5.1846
P407
P577
1999-03-01T00:00:00Z