Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.
about
PfCRT and its role in antimalarial drug resistanceIdentification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparumOn the mechanism of chloroquine resistance in Plasmodium falciparumFunctional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesiclesMolecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance TransporterChloroquine transport via the malaria parasite's chloroquine resistance transporterMultiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sitesExperimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites.Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum1H-NMR metabolite profiles of different strains of Plasmodium falciparum.Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytesDifferential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.Chloroquine transport in Plasmodium falciparum. 2. Analysis of PfCRT-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe.Antimalarial drugs: modes of action and mechanisms of parasite resistance.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Membrane transport in the malaria parasite and its host erythrocyte.Role of Different Pfcrt and Pfmdr-1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum.Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.Malaria treatment using novel nano-based drug delivery systems.Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum.Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter
P2860
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P2860
Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Chloroquine resistance-conferr ...... parasite's digestive vacuole.
@en
type
label
Chloroquine resistance-conferr ...... parasite's digestive vacuole.
@en
prefLabel
Chloroquine resistance-conferr ...... parasite's digestive vacuole.
@en
P2860
P921
P356
P1476
Chloroquine resistance-conferr ...... parasite's digestive vacuole.
@en
P2860
P304
P356
10.1128/AAC.00666-08
P407
P577
2008-10-13T00:00:00Z