PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
about
PfCRT and its role in antimalarial drug resistanceThe molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transportersGenome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt geneOn the mechanism of chloroquine resistance in Plasmodium falciparumFunctional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesiclesMolecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance TransporterEvolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole PhysiologyChloroquine transport via the malaria parasite's chloroquine resistance transporterStage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy.Predictive computational models of substrate binding by a nucleoside transporter.Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporterQuinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparumAnalysis of gene mutations involved in chloroquine resistance in Plasmodium falciparum parasites isolated from patients in the southwest of Saudi ArabiaRuthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity.Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria1H-NMR metabolite profiles of different strains of Plasmodium falciparum.Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.PfCRT-mediated drug transport in malarial parasites.Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter.Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.Antimalarial quinolones: synthesis, potency, and mechanistic studiesDrug-resistant malaria - an insight.Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.Chloroquine is grossly overdosed and overused but well tolerated in Guinea-bissau.Recent highlights in antimalarial drug resistance and chemotherapy research.Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquineChloroquine transport in Plasmodium falciparum. 2. Analysis of PfCRT-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe.Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review.Antimalarial drugs: modes of action and mechanisms of parasite resistance.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe.Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.Detecting mutations in PfCRT and PfMDR1 genes among Plasmodium falciparum isolates from Saudi Arabia by pyrosequencing.Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity.Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes.Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum.Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine.Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues.Dissecting the components of quinine accumulation in Plasmodium falciparum.Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
P2860
Q27861957-E1C4F752-2979-4CB5-BD3B-7F0A3577CEBBQ27972580-56DE6556-9754-40FF-8E29-4189132134A1Q28472981-E85BB3A3-B1FE-4626-807C-06633F125099Q28476197-1CB2C141-3D96-4A60-AA44-FA45919AB185Q28480526-95E72F6C-95AA-4544-91A7-F8B8E1EED33BQ28552775-D09D6E6C-62DF-4B94-90A0-9FBB2485CFC2Q28553454-CDCFABE0-6941-4DB3-865C-BC2525409879Q30041673-62077951-6EC8-4C41-B09C-DB752CC5AC43Q33320129-04C37176-1EB5-43AF-A28F-FAC4E1ACE62CQ33553416-AAB37480-3F52-4C7D-8F01-07757E48DBCEQ33674606-4213ACC4-A437-48FC-B20C-6D5E08A7175EQ33797050-71C7807E-0D48-4F9C-BEF5-0C55C59156FDQ33918006-97709820-D598-4C55-82B7-7503092E7A85Q34128946-25022340-5312-49AF-AB67-CC8E88881BF8Q34204687-69AC737B-A501-44AB-AA0E-C02DC3519F5CQ34554760-0F368E22-9ED5-462D-9B51-C4F8C4E89B7EQ34932500-C5324EB6-E943-43E6-948E-DCB7F3061EEAQ35069586-8ABDFCC1-8CBF-4556-88EA-66A598CDF515Q35212623-02A5CCDE-C5E4-4157-9501-2471CA65EB54Q36276918-AD212A75-BFCC-46B9-B8CB-1ECFD744DB8BQ36571059-33389BEB-3EC2-4C0C-850C-BB1AC216CF06Q36933785-5F749E0A-C6A0-4F39-8F9B-27665E146A4FQ36993537-6130D840-DF77-49B9-AA36-DD9B0285B800Q37032859-039395FF-0126-4871-839A-4E07502DADB2Q37283037-DCB84A1B-912B-47D4-9D2B-8311B15BB1B3Q37299785-4E85C32E-E076-4F37-8C7E-E8145F9621A4Q37423375-87B0F7C6-0D7E-4ACA-9D6D-074F9D076067Q37721293-01E47659-FE79-4E2C-93FC-0089C447C0DBQ37820670-D1986DC7-87F2-4EA9-B424-AEC466DF385CQ37979631-09EDECBF-C3A8-47AC-BD18-A7CE4555B39DQ41869427-00E83DB2-2276-4971-800D-126CBE99C15DQ41916522-1D71DA58-E09B-45F3-B61E-1EDC84DF68DCQ41933380-8339555F-AAA8-42CD-9CBE-F40B3CCC65D1Q41937324-2BA101F6-FC7B-42A7-8165-92DDF09B9CC8Q41937826-391944A2-9D61-42C9-A0A4-EFD21F77D4C4Q41943028-A23C75EA-5E86-483A-8C38-2E05400D9FACQ41943991-6ED99FEA-D267-488F-BA8B-5C3EF14C7A0BQ42726942-C7D14D90-5104-4E1A-801F-FBC16AD2620BQ46808989-B033CBC5-A066-4C7A-97F7-EFDF2F77C311Q56342194-E38035E7-EAE9-4451-BDA4-3C53494FEB45
P2860
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@ast
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@en
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@nl
type
label
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@ast
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@en
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@nl
prefLabel
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@ast
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@en
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@nl
P2093
P2860
P50
P921
P1476
PfCRT and the trans-vacuolar p ...... ine to ferriprotoporphyrin IX.
@en
P2093
Dauda K Saidu
David C Warhurst
David J Johnson
Ian M Hastings
Patrick G Bray
Paul A Stocks
Paul M O'Neill
Ruth H Hughes
Stephen A Ward
Viswanathan Lakshmanan
P2860
P304
P356
10.1111/J.1365-2958.2006.05368.X
P407
P577
2006-08-31T00:00:00Z