Securin is a target of the UV response pathway in mammalian cells

Securin is a target of the UV response pathway in mammalian cells

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http://www.wikidata.org/entity/Q37012717
Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cellsCohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatinNaturally occurring and stress induced tubular structures from mammalian cells, a survival mechanism.SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stabilityGlycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility.Cohesin: a regulator of genome integrity and gene expression.Pituitary tumor-transforming gene and its binding factor in endocrine cancer.βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy.Securin and separase modulate membrane traffic by affecting endosomal acidification.Identification of a nuclear-localized nuclease from wheat cells undergoing programmed cell death that is able to trigger DNA fragmentation and apoptotic morphology on nuclei from human cells.Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells.Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase.Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer
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Securin is a target of the UV response pathway in mammalian cells

Item
http://www.wikidata.org/entity/Q37012717
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on April 2004
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Securin is a target of the UV response pathway in mammalian cells
@en
Securin is a target of the UV response pathway in mammalian cells.
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type
label
Securin is a target of the UV response pathway in mammalian cells
@en
Securin is a target of the UV response pathway in mammalian cells.
@nl
prefLabel
Securin is a target of the UV response pathway in mammalian cells
@en
Securin is a target of the UV response pathway in mammalian cells.
@nl
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Securin is a target of the UV response pathway in mammalian cells
@en
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P2860
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P356
10.1128/MCB.24.7.2720-2733.2004
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