Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. - Test2 - elhamkhani - TriplyDB

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

http://www.wikidata.org/entity/Q37109336

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The same pocket in menin binds both MLL and JUND but has opposite effects on transcription Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors.An MLL-dependent network sustains hematopoiesis.Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9.HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis.Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.Menin and bone metabolism.Menin as a hub controlling mixed lineage leukemia.The role of menin in hematopoiesis Trithorax and polycomb cooperation in MLL fusion acute leukemia.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

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Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

http://www.wikidata.org/entity/Q37109336

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on February 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

@en

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

@nl

type

label

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

@en

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

@nl

prefLabel

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

@en

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

@nl

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BLOOD-2008-01-135012

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Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

@en

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Ann Friedman

http://www.w3.org/2001/XMLSchema#string

Anthony T Tubbs

http://www.w3.org/2001/XMLSchema#string

Ivan Maillard

http://www.w3.org/2001/XMLSchema#string

Olga Shestova

http://www.w3.org/2001/XMLSchema#string

Warren S Pear

http://www.w3.org/2001/XMLSchema#string

Xianxin Hua

http://www.w3.org/2001/XMLSchema#string

Ya-Xiong Chen

http://www.w3.org/2001/XMLSchema#string

Yuqing Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Molecular pathology of the MEN1 gene

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice

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1661-1669

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scholarly article

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10.1182/BLOOD-2008-01-135012

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113

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2009-02-01T00:00:00Z

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19228930

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2647667

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