A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.
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Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2pEvidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activityPhosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae.Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsSnf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Auto-phosphorylation Represses Protein Kinase R Activity.Integrated Stress Responses to Bacterial Pathogenesis Patterns.
P2860
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P2860
A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 29 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A network of hydrophobic resid ...... anslation initiation factor 2.
@en
A network of hydrophobic resid ...... anslation initiation factor 2.
@nl
type
label
A network of hydrophobic resid ...... anslation initiation factor 2.
@en
A network of hydrophobic resid ...... anslation initiation factor 2.
@nl
prefLabel
A network of hydrophobic resid ...... anslation initiation factor 2.
@en
A network of hydrophobic resid ...... anslation initiation factor 2.
@nl
P2093
P2860
P356
P1476
A network of hydrophobic resid ...... ranslation initiation factor 2
@en
P2093
Alan G Hinnebusch
Andrés Gárriz
Eun-Joo Seo
Hongfang Qiu
Madhusudan Dey
P2860
P304
P356
10.1128/MCB.01446-08
P407
P50
P577
2008-12-29T00:00:00Z