The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. - Test2 - elhamkhani - TriplyDB

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

http://www.wikidata.org/entity/Q37143515

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Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase from Enterococcus faecalis The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1 GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state Analysis of DNA-damage response to ionizing radiation in serum-shock synchronized human fibroblasts.SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Structural basis of cellular dNTP regulation by SAMHD1.SAMHD1 prevents autoimmunity by maintaining genome stability.A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1 SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.Structure of Escherichia coli dGTP triphosphohydrolase: a hexameric enzyme with DNA effector molecules.A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice.Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592 The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.Phosphorylation of murine SAMHD1 regulates its antiretroviral activity Structural Insights into the High-efficiency Catalytic Mechanism of the Sterile α-Motif/Histidine-Aspartate Domain-containing Protein.Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1 Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance GTP is the primary activator of the anti-HIV restriction factor SAMHD1.Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes.Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.Proteomic Profiling of Hematopoietic Stem/Progenitor Cells after a Whole Body Exposure of CBA/CaJ Mice to Titanium (48Ti) Ions.Deoxyribonucleotides as genetic and metabolic regulators Mitochondrial dysfunction: a neglected component of skin diseases.Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.

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The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

http://www.wikidata.org/entity/Q37143515

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 15 July 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The deoxynucleotide triphospho ...... rsor pools in mammalian cells.

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The deoxynucleotide triphospho ...... rsor pools in mammalian cells.

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type

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The deoxynucleotide triphospho ...... rsor pools in mammalian cells.

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The deoxynucleotide triphospho ...... rsor pools in mammalian cells.

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prefLabel

The deoxynucleotide triphospho ...... rsor pools in mammalian cells.

@en

The deoxynucleotide triphospho ...... rsor pools in mammalian cells.

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PNAS.1312033110

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Proceedings of the National Academy of Sciences of the United States of America

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The deoxynucleotide triphospho ...... ursor pools in mammalian cells

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Chiara Rampazzo

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Cristina Miazzi

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Elisa Franzolin

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Giovanna Pontarin

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Paola Ferraro

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Peter Reichard

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Vera Bianchi

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P2860

Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder

Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate

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10.1073/PNAS.1312033110

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