Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.

Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.

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http://www.wikidata.org/entity/Q37166784
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.Role of Innate Genes in HIV Replication.Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T Cells.CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.Uncovering allostery and regulation in SAMHD1 through molecular dynamics simulations.A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1
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Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.

Item
http://www.wikidata.org/entity/Q37166784
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 August 2016
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Effects of T592 phosphomimetic ...... retroviral restriction defect.
@en
Effects of T592 phosphomimetic ...... retroviral restriction defect.
@nl
type
label
Effects of T592 phosphomimetic ...... retroviral restriction defect.
@en
Effects of T592 phosphomimetic ...... retroviral restriction defect.
@nl
prefLabel
Effects of T592 phosphomimetic ...... retroviral restriction defect.
@en
Effects of T592 phosphomimetic ...... retroviral restriction defect.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P698
P932
P356
P1433
P1476
Effects of T592 phosphomimetic ...... retroviral restriction defect
@en
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P698
P932