Biosynthesis of sibiromycin, a potent antitumor antibiotic. - Test2 - elhamkhani - TriplyDB

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

http://www.wikidata.org/entity/Q37191100

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Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway Structure and activity of NADPH-dependent reductase Q1EQE0 from Streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis Identification and characterization of new family members in the tautomerase superfamily: analysis and implications Screening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara Soils Anthranilate-activating modules from fungal nonribosomal peptide assembly lines The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetales Aminobenzoates as building blocks for natural product assembly lines.Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis.Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycin Lincomycin biosynthesis involves a tyrosine hydroxylating heme protein of an unusual enzyme family.Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism.Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase.Mutasynthesis of a potent anticancer sibiromycin analogue Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog.Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.The redox cofactor F420 protects mycobacteria from diverse antimicrobial compounds and mediates a reductive detoxification system.Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin.New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C-C Bond?Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway.Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1.Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis.Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937 4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage Sequence analysis of porothramycin biosynthetic gene cluster.Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci.Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.An Activator of an Adenylation Domain Revealed by Activity but Not Sequence Homology.The novel transcriptional regulator LmbU promotes lincomycin biosynthesis through regulating expression of its target genes in Streptomyces lincolnensis.Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid.An ortho C-methylation/O-glycosylation motif on a hydroxy-coumarin scaffold, selectively installed by biocatalysis.Dual gold/photoredox-catalyzed bis-arylative cyclization of chiral homopropargyl sulfonamides with diazonium salts: rapid access to enantioenriched 2,3-dihydropyrroles.Hypervalent iodine-triggered transformation of homopropargyl sulfonamides into dihalo-2,3-dihydropyrroles.Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications.Identification and Characterization of Mycemycin Biosynthetic Gene Clusters in Streptomyces olivaceus FXJ8.012 and Streptomyces sp. FXJ1.235.Dual-role of PtCl2 catalysis in the intramolecular cyclization of (hetero)aryl-allenes for the facile construction of substituted 2,3-dihydropyrroles and polyheterocyclic skeletons.

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Biosynthesis of sibiromycin, a potent antitumor antibiotic.

http://www.wikidata.org/entity/Q37191100

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 06 March 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

@en

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

@nl

type

label

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

@en

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

@nl

prefLabel

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

@en

Biosynthesis of sibiromycin, a potent antitumor antibiotic.

@nl

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Applied and Environmental Microbiology

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Biosynthesis of sibiromycin, a potent antitumor antibiotic.

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Ankush Khullar

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Ashley Sacramo

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Barbara Gerratana

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Shenchieh Chou

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Wei Li

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The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136

The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad

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2869-2878

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scholarly article

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10.1128/AEM.02326-08

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9

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75

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2009-03-06T00:00:00Z

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24185658

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19270142

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2681668

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