UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
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MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and TumorigenesisProtein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Control of mitochondrial biogenesis and function by the ubiquitin-proteasome systemA novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesisMotor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine DiseaseTuning the proteasome to brighten the end of the journey.Molecular definitions of autophagy and related processes.The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.Ubiquitin recognition by the proteasome.Designer protein disaggregases to counter neurodegenerative disease.Ubiquitin and Parkinson's disease through the looking glass of genetics.New routes in frontotemporal dementia drug discovery.Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.Investigation of the adaptor protein PLIC-2 in multiple pathwaysUbiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.Ubiquitin ligases in oncogenic transformation and cancer therapy.An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease.Pathways of cellular proteostasis in aging and disease.Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration.In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.Ageing as a risk factor for ALS/FTD.Nuclear export of ubiquitinated proteins via the UBIN-POST system.Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis.Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation.Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease.The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.Amyotrophic lateral sclerosisMutant UBQLN2 promotes toxicity by modulating intrinsic self-assemblyAmyloid assembly and disassemblyUbiquilin 2: Shuttling Clients Out of Phase?
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UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 July 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
@en
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
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label
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
@en
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
@nl
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UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
@en
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
@nl
P2093
P2860
P50
P1433
P1476
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
@en
P2093
Axel Knebel
Clare Johnson
Francesco Marchesi
Georgina Osborne
Indrajit Sahu
Joby Varghese
John S Bett
Matthew J Keuss
Melanie Wightman
Roland Hjerpe
P2860
P304
P356
10.1016/J.CELL.2016.07.001
P407
P50
P577
2016-07-27T00:00:00Z