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The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiaeDcn1 functions as a scaffold-type E3 ligase for cullin neddylationA Dual E3 Mechanism for Rub1 Ligation to Cdc53Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulationCullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical StressThe TFIIH subunit Tfb3 regulates cullin neddylation.The COP9 signalosome is vital for timely repair of DNA double-strand breaks.Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during early C. elegans embryogenesis.UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranesWNK signalling pathways in blood pressure regulationROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes.Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers.Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway.The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans.CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.The Dac-tag, an affinity tag based on penicillin-binding protein 5.The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.The Cullin Rtt101p Promotes Replication Fork Progression through Damaged DNA and Natural Pause SitesUnanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell deathNEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway
P50
Q24306410-942E2819-322F-41D4-9748-F394BCFF8B3AQ27649565-F57AF8F0-CC41-42C8-AA5E-A468C2CBE00DQ27664416-D97764CA-040A-49D1-BD45-B8C1C6497B62Q27682289-5C83DCE3-4144-466C-9CB3-231937817237Q27932725-E9315BE6-0F74-41E4-A758-178797EF6D5EQ28553458-39636836-D717-4A59-AE49-04B1E8DD2CF3Q35266319-68B5B140-B05E-4AF5-85B5-1B300BACD4B0Q35786094-130E779F-248C-4960-865A-E17382F695E4Q36159459-492C1D96-2715-468A-867F-DE094C6ECD59Q36392573-5415A21F-4C84-4491-9586-4A3B79661EB8Q37214887-5CCBF70C-CD3D-4241-8454-8E884C4D2361Q37282361-35BC938D-9E46-46C9-9BBD-8FE0FFB0D37AQ37694287-606413CA-00AC-44FA-B008-7B8DA983172BQ38759831-3610DF83-B160-47AE-845B-B5CFA684FCCBQ38791699-210D58A2-9C00-4C30-9CD4-1F65BBD53AB9Q39986392-FDE3975F-B73E-47DD-9820-4A949D806740Q41141041-DAD11711-6973-4FA4-88D3-99D9D8638E69Q43180105-E08055CE-F78E-46FA-A15F-5CADF6B33DD4Q43888176-A797AECC-AE8B-4B08-B831-7806291371BDQ47069071-779D3A87-A019-4D65-83CA-B87ED13B9686Q47069590-9EFA591B-A6AD-4EBC-8878-7C822EA00720Q50336194-820FF7E0-7E33-4034-BBE0-34AE47283E96Q50495118-D4A3AC4D-0CB7-4CE6-B833-3811510E0692Q55488054-5D22D7FA-8889-40E9-8F70-8A52E00F892CQ63965584-1A98854E-1A8B-4A64-84BE-0186B7BD14F7Q63976958-252F502F-3156-4622-9E37-31F82460DE29Q63976960-6E5050B8-C6A0-4B43-A51A-60A446D5DD1A
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Thimo Kurz
@ast
Thimo Kurz
@en
Thimo Kurz
@es
Thimo Kurz
@nl
Thimo Kurz
@sl
type
label
Thimo Kurz
@ast
Thimo Kurz
@en
Thimo Kurz
@es
Thimo Kurz
@nl
Thimo Kurz
@sl
prefLabel
Thimo Kurz
@ast
Thimo Kurz
@en
Thimo Kurz
@es
Thimo Kurz
@nl
Thimo Kurz
@sl
P106
P1153
7006115764
P21
P31
P496
0000-0003-0700-6993