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The Growing Complexity of Cancer Cell Response to DNA-Damaging Agents: Caspase 3 Mediates Cell Death or Survival?Influence of parameter values on the oscillation sensitivities of two p53-Mdm2 modelsAnother fork in the road--life or death decisions by the tumour suppressor p53Stochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damageInvolvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction.Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathwaysEnhancement of tunability of MAPK cascade due to coexistence of processive and distributive phosphorylation mechanisms.Interplay between Mdm2 and HIPK2 in the DNA damage response.Dynamics of posttranslational modifications of p53.WIP1 phosphatase as pharmacological target in cancer therapy.The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal developmentNoise amplification in human tumor suppression following gamma irradiation.MicroRNA-mediated positive feedback loop and optimized bistable switch in a cancer network Involving miR-17-92.Reversible and noisy progression towards a commitment point enables adaptable and reliable cellular decision-making.Modeling the basal dynamics of p53 system.Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage.Dynamic modelling of oestrogen signalling and cell fate in breast cancer cellsA two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities.Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model.Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cellsBayesian parameter inference by Markov chain Monte Carlo with hybrid fitness measures: theory and test in apoptosis signal transduction networkTwo-phase dynamics of p53 in the DNA damage response.Coordination between p21 and DDB2 in the cellular response to UV radiation.p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damageRole of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.The role of mRNA decay in p53-induced gene expressionPDCD5-regulated cell fate decision after ultraviolet-irradiation-induced DNA damage.MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer CellsCoordination of the nuclear and cytoplasmic activities of p53 in response to DNA damageMutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis.Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 SystemRegulation of the DNA damage response by p53 cofactorsDynamic mechanism for the transcription apparatus orchestrating reliable responses to activators.Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis.Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle ArrestIdentification of the molecular mechanisms for cell-fate selection in budding yeast through mathematical modeling.Engineering dynamical control of cell fate switching using synthetic phospho-regulons.Dynamics of p53: A Master Decider of Cell Fate.Novel strategies for drug discovery based on Intrinsically Disordered Proteins (IDPs)Systems biology of cellular rhythms.
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cell fate decision mediated by p53 pulses
@en
Cell fate decision mediated by p53 pulses.
@nl
type
label
Cell fate decision mediated by p53 pulses
@en
Cell fate decision mediated by p53 pulses.
@nl
prefLabel
Cell fate decision mediated by p53 pulses
@en
Cell fate decision mediated by p53 pulses.
@nl
P2860
P50
P356
P1476
Cell fate decision mediated by p53 pulses
@en
P2093
P2860
P304
12245-12250
P356
10.1073/PNAS.0813088106
P407
P577
2009-07-15T00:00:00Z