Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions
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Q&A: epistasisEpistasis--the essential role of gene interactions in the structure and evolution of genetic systemsFunctional organization of the S. cerevisiae phosphorylation networkReplication-Associated Recombinational Repair: Lessons from Budding YeastFunctions and regulation of the multitasking FANCM family of DNA motor proteinsEpistasis and quantitative traits: using model organisms to study gene-gene interactionsGenetic interaction networks: better understand to better predictEpistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alphaThe genetic basis of natural variation in oenological traits in Saccharomyces cerevisiae.A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis.Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repairGlobal analysis of yeast endosomal transport identifies the vps55/68 sorting complexEsc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.Comprehensive characterization of genes required for protein folding in the endoplasmic reticulumThe yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity.Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.The genetic landscape of a cellComparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agentsOff-target effects of psychoactive drugs revealed by genome-wide assays in yeastEpistatic interaction maps relative to multiple metabolic phenotypesQuantitative epistasis analysis and pathway inference from genetic interaction dataMitochondrial electron transport is the cellular target of the oncology drug elesclomolSystematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genesA novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2Maximal extraction of biological information from genetic interaction dataPairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.Molecular mechanisms of system responses to novel stimuli are predictable from public dataFunctional maps of protein complexes from quantitative genetic interaction data.Genetic evidence for a phosphorylation-independent signal transduction mechanism within the Bacillus subtilis stressosomeSystematic validation and atomic force microscopy of non-covalent short oligonucleotide barcode microarrays.Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination.Pervasive and persistent redundancy among duplicated genes in yeastA comprehensive strategy enabling high-resolution functional analysis of the yeast genome.Predicting quantitative genetic interactions by means of sequential matrix approximationCombination chemical geneticsPredicting genetic interactions with random walks on biological networks.Positive epistasis drives the acquisition of multidrug resistance.Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganismsReverse engineering a signaling network using alternative inputs
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Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 07 January 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Systematic pathway analysis us ...... f combinatorial gene deletions
@en
Systematic pathway analysis us ...... combinatorial gene deletions.
@nl
type
label
Systematic pathway analysis us ...... f combinatorial gene deletions
@en
Systematic pathway analysis us ...... combinatorial gene deletions.
@nl
prefLabel
Systematic pathway analysis us ...... f combinatorial gene deletions
@en
Systematic pathway analysis us ...... combinatorial gene deletions.
@nl
P2093
P2860
P356
P1433
P1476
Systematic pathway analysis us ...... f combinatorial gene deletions
@en
P2093
Guri Giaever
Michael Proctor
Ramamurthy Mani
Robert P St Onge
Ronald W Davis
P2860
P2888
P304
P356
10.1038/NG1948
P407
P577
2007-01-07T00:00:00Z