about
Proteoglycan form and function: A comprehensive nomenclature of proteoglycansEndorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonismDecorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cellsMITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancerA central function for perlecan in skeletal muscle and cardiovascular developmentEndothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathwayPerlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesisMechanisms of Progranulin Action and Regulation in Genitourinary CancersThe role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagyDecoding the Matrix: Instructive Roles of Proteoglycan ReceptorsThrombospondins in physiology and disease: new tricks for old dogsThe biology of small leucine-rich proteoglycans in bone pathophysiologyBiological interplay between proteoglycans and their innate immune receptors in inflammationInsights into the key roles of proteoglycans in breast cancer biology and translational medicineThe biology of the small leucine-rich proteoglycans. Functional network of interactive proteinsFibroblast growth factor-binding protein is a novel partner for perlecan protein coreOverexpression of bamacan/SMC3 causes transformationDecorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitopeEndorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecanSignaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23Characterization of the complete genomic structure of the human WNT-5A gene, functional analysis of its promoter, chromosomal mapping, and expression in early human embryogenesisThe degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanasesMatrix proteoglycans: from molecular design to cellular functionDecorin is a biological ligand for the epidermal growth factor receptorBMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecanStructural and functional characterization of the human perlecan gene promoter. Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding elementαvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor.A current view of perlecan in physiology and pathology: A mosaic of functions.A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin.Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells.Biologically active decorin is a monomer in solution.A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth.Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturationMyeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan.Biglycan and decorin differentially regulate signaling in the fetal membranesDecorin differentially modulates the activity of insulin receptor isoform A ligands.Decorin deficiency promotes hepatic carcinogenesis
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
ricercatore
@it
հետազոտող
@hy
name
Renato V Iozzo
@nl
Renato V Iozzo
@sl
Renato V. Iozzo
@en
Renato V. Iozzo
@es
type
label
Renato V Iozzo
@nl
Renato V Iozzo
@sl
Renato V. Iozzo
@en
Renato V. Iozzo
@es
prefLabel
Renato V Iozzo
@nl
Renato V Iozzo
@sl
Renato V. Iozzo
@en
Renato V. Iozzo
@es
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P214
P244
P5361
P1006
P106
P1153
35511430300
P21
P213
0000 0001 0981 0251
P214
P244
P31
P496
0000-0002-5908-5112
P5361
IozzoRenatoV1950-
P569
1950-11-19T00:00:00Z
P735
P7859
lccn-n00001042