Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
about
Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysisProteoglycan form and function: A comprehensive nomenclature of proteoglycansMULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathwayEndorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonismEndorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cellsThe role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagyDecoding the Matrix: Instructive Roles of Proteoglycan ReceptorsExtracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning.Extracellular Matrix, a Hard Player in AngiogenesisA current view of perlecan in physiology and pathology: A mosaic of functions.Similarity of recombinant human perlecan domain 1 by alternative expression systems bioactive heterogenous recombinant human perlecan D1.Endorepellin evokes autophagy in endothelial cellsSoluble perlecan domain I enhances vascular endothelial growth factor-165 activity and receptor phosphorylation in human bone marrow endothelial cells.Perlecan maintains microvessel integrity in vivo and modulates their formation in vitroHeparan sulfate proteoglycans.D-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.Pathophysiological changes to the peritoneal membrane during PD-related peritonitis: the role of mesothelial cells.Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation.Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear factThe role of extracellular matrix in vascular branching morphogenesisEndostatin and endorepellin: A common route of action for similar angiostatic cancer avengersProteoglycans in cancer biology, tumour microenvironment and angiogenesis.Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept.The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.Differentiation of Human Embryonic Stem Cells to Endothelial Progenitor Cells on Laminins in Defined and Xeno-free Systems.Border patrol: insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue bordersHeparan sulfate in angiogenesis: a target for therapy.Localization of VEGF to Vascular ECM Is an Important Aspect of Tumor Angiogenesis.Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology.The nature and biology of basement membranes.Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase.Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan.MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA).Proteome-based biomarkers in pancreatic cancer.VEGF synthesis is induced by prostacyclin and TGF-β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling.Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation.Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.
P2860
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P2860
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis
@nl
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
@ast
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
@en
type
label
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis
@nl
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
@ast
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
@en
prefLabel
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis
@nl
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
@ast
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.
@en
P2860
P3181
P1433
P1476
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis
@en
P2093
Jason J Zoeller
P2860
P304
P3181
P356
10.1016/J.MATBIO.2009.04.010
P407
P577
2009-05-05T00:00:00Z