Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B
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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeA conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivityStructural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteineDesign and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitorsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsIdentification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3Bioactive marine drugs and marine biomaterials for brain diseasesCDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiationPharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) inhibitorsDesign and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I.Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme.Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress.Recent progress in neuroactive marine natural products.Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms.DYRK1A inhibition as potential treatment for Alzheimer's disease.Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease.Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases.Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.Predicting targets of compounds against neurological diseases using cheminformatic methodology.Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer's Disease Therapeutic Agents.A Challenging Pie to Splice: Drugging the Spliceosome.Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome.Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents.Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives.Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions.Synthesis of 2-Aminoimidazolones and Imidazolones by (3 + 2) Annulation of Azaoxyallyl Cations.New 5-ylidene rhodanine derivatives based on the dispacamide A model.Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma.Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer's Disease: A Computational StudyDevelopment of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-]-quinazolin-9-ones Designed by Fragment-Growing Studies
P2860
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P2860
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@ast
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@en
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@nl
type
label
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@ast
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@en
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@nl
prefLabel
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@ast
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@en
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@nl
P2093
P50
P3181
P356
P1476
Selectivity, cocrystal structu ...... sponge alkaloid leucettamine B
@en
P2093
Anselm E Oberholzer
Claude Cochet
Donald C Lo
Emilie Durieu
François Carreaux
Guillaume Burgy
Jean-Pierre Bazureau
Laurent Meijer
Tania Tahtouh
P304
P3181
P356
10.1021/JM301034U
P407
P50
P577
2012-11-08T00:00:00Z