about
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretaseMolecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidasesPresenilin 2 regulates the systolic function of heart by modulating Ca2+ signalingAPP processing and synaptic functionNovel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.Three-dimensional structure of the signal peptide peptidaseBACE1 activity is modulated by cell-associated sphingosine-1-phosphate.A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysisA novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substratesSingle chain variable fragment against nicastrin inhibits the gamma-secretase activity.Secretase inhibitors and modulators for Alzheimer's disease treatment.Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generationDifferentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signalingStructural biology of presenilins and signal peptide peptidases.Protein trafficking and maturation regulate intramembrane proteolysis.Molecular mechanism of intramembrane proteolysis by γ-secretase.Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease.Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease.Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's.Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.S-palmitoylation of gamma-secretase subunits nicastrin and APH-1The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Taisuke Tomita
@ast
Taisuke Tomita
@en
Taisuke Tomita
@es
Taisuke Tomita
@nl
Taisuke Tomita
@sl
type
label
Taisuke Tomita
@ast
Taisuke Tomita
@en
Taisuke Tomita
@es
Taisuke Tomita
@nl
Taisuke Tomita
@sl
prefLabel
Taisuke Tomita
@ast
Taisuke Tomita
@en
Taisuke Tomita
@es
Taisuke Tomita
@nl
Taisuke Tomita
@sl
P1053
L-5427-2015
P106
P1153
7403060061
P21
P2798
P31
P3829
P496
0000-0002-0075-5943
P569
2000-01-01T00:00:00Z