Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. - Test2 - elhamkhani - TriplyDB

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

http://www.wikidata.org/entity/Q37459837

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Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.Camelid heavy chain only antibody fragment domain against β-site of amyloid precursor protein cleaving enzyme 1 inhibits β-secretase activity in vitro and in vivo.Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo Antibody-based therapy in Alzheimer's disease.The Nicastrin ectodomain adopts a highly thermostable structure.Intracellular antibodies and cancer: new technologies offer therapeutic opportunities.Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum.High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100

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P2860

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

http://www.wikidata.org/entity/Q37459837

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 14 August 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

@en

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

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type

label

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

@en

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

@nl

prefLabel

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

@en

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

@nl

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JBC.M109.055061

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Journal of Biological Chemistry

P1476

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity

@en

P2093

Hiroko Iwanari

http://www.w3.org/2001/XMLSchema#string

Ikuo Hayashi

http://www.w3.org/2001/XMLSchema#string

Maiko A Fukuda

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Noriko Isoo

http://www.w3.org/2001/XMLSchema#string

Philip C Wong

http://www.w3.org/2001/XMLSchema#string

Satoko Osawa

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Takao Hamakubo

http://www.w3.org/2001/XMLSchema#string

Takeshi Iwatsubo

http://www.w3.org/2001/XMLSchema#string

Tatsuhiko Kodama

http://www.w3.org/2001/XMLSchema#string

Tong Li

http://www.w3.org/2001/XMLSchema#string

P2860

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

Getting in and out from calnexin/calreticulin cycles

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control

Building gamma-secretase: the bits and pieces

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

Gamma-secretase complex assembly within the early secretory pathway

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

P304

27838-27847

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10.1074/JBC.M109.055061

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41

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2009-08-14T00:00:00Z

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19684016

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2788834

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