Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase
about
The amyloid hypothesis of Alzheimer's disease at 25 yearsThe roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer diseaseEffects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearanceAn intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoformThe Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis.The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia.Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's diseaseATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.Molecular mechanism of intramembrane proteolysis by γ-secretase.Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomesClearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.Untangling Genetic Risk for Alzheimer's Disease.Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.Forty years on: clathrin-coated pits continue to fascinateAmyloid-β and tau complexity - towards improved biomarkers and targeted therapies.Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
P2860
Q26749528-600B0880-E3F7-48FF-9891-C8A4BBE3ADF3Q26777969-95C0D76B-40B0-4DEA-B14B-921483154F6AQ30009187-CF0787C1-61C8-4716-8D66-EBF78C3D9B03Q30090186-0496440F-EE5E-4B10-A28D-E1F05996E613Q34115046-583EB6EA-D8C1-4E63-9911-879CDA194634Q34324323-436F8688-1C47-47CC-BC93-42E5B0EA1773Q35126571-BF017DFE-8DFB-4ABB-9D21-B5AE2B16E852Q35663837-FEA368F0-E448-4962-B9B8-8C88A83EF718Q35939019-AC566E71-8A85-47C5-BB16-82DD30005E02Q36080682-07A0DD0B-1A37-4BED-AC6F-3D0E5CCCE71AQ36115792-C2C57E34-2DAF-4814-A2D3-C7A5760F8D84Q38238454-22D148D2-0DF0-434B-828E-A0DA865EBA22Q38433126-974767B3-CBEF-409D-AF30-2BED647EDE59Q38942020-7EE8BC62-4EB3-4EDA-9AB1-3D462ADC8886Q39135845-A92B7D42-EDD6-4089-841F-D3F374D734B0Q39407560-628F51AA-DC27-4B18-A095-64D8EA6BD2BEQ41665323-09ECBC2D-4138-45A8-9AE0-71A28BB755A3Q42266897-540F9110-BD33-4A09-94A1-8918B576156DQ46240783-F6615970-6FD7-4445-897F-40E09E11AA64Q46510077-D312DFF0-A7F3-444A-9646-8C065D1FDB8CQ48736362-89AD4413-25FD-4AD5-85DC-A919A5D52C8A
P2860
Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@ast
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@en
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@en-gb
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@nl
type
label
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@ast
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@en
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@en-gb
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@nl
prefLabel
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@ast
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@en
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@en-gb
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@nl
P2093
P2860
P921
P3181
P356
P1476
Decreased CALM expression redu ...... ted endocytosis of γ-secretase
@en
P2093
Hiromasa Kuroda
Kunihiko Kanatsu
Mai Suzuki
Takeshi Iwatsubo
Toshio Watanabe
Yuichi Morohashi
P2860
P2888
P3181
P356
10.1038/NCOMMS4386
P407
P577
2014-01-01T00:00:00Z
P6179
1037787267