about
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivoMAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in miceStudies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agentsType I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structureIdentification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl ReductaseBiochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory FactorThe benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme targetDelivery of antimicrobials into parasitesParasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivoTriclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.Evolutionary origins of the eukaryotic shikimate pathway: gene fusions, horizontal gene transfer, and endosymbiotic replacements.Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.Sex-associated hormones and immunity to protozoan parasites.The shikimate pathway and its branches in apicomplexan parasites.Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion.Toxoplasma gondii tachyzoite-bradyzoite interconversion.Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 miceSex steroids, pregnancy-associated hormones and immunity to parasitic infection.Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase.Immunological control of congenital toxoplasmosis in the murine model.New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondiiVaccines against Toxoplasma gondii: challenges and opportunities.Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections.Immunogenetics of Toxoplasma gondii informs vaccine design.Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba.Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.Differential cytotoxicity of phospholipid analogues to pathogenic Acanthamoeba species and mammalian cells.Acanthamoeba Activates Macrophages Predominantly through Toll-Like Receptor 4- and MyD88-Dependent Mechanisms To Induce Interleukin-12 (IL-12) and IL-6.DNA vaccination with the immunodominant tachyzoite surface antigen (SAG-1) protects against adult acquired Toxoplasma gondii infection but does not prevent maternofoetal transmission.Acanthamoeba castellanii Genotype T4 Stimulates the Production of Interleukin-10 as Well as Proinflammatory Cytokines in THP-1 Cells, Human Peripheral Blood Mononuclear Cells, and Human Monocyte-Derived MacrophagesDevelopment of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba.Immunological control of Toxoplasma gondii and appropriate vaccine design.The Acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis.Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.Acanthamoeba alternative oxidase genes: identification, characterisation and potential as antimicrobial targets.Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo.
P50
Q21092310-A95B75CB-55FC-4D6B-9013-181D04E3B0B9Q27334138-1A98E41D-CD8C-465F-AB59-145C3EBB171DQ27643926-B9991134-B107-4B22-8994-3175CE9651DFQ27647201-8220F2A1-7017-4511-B061-E8B1C46C866AQ27664019-979B73DA-128C-4584-868A-8081489B239FQ27676640-F1B5EF12-0D0D-4511-B69A-0FE379EA3087Q27681222-5DFEE0D6-F3CC-4D40-BC25-49B987DC9B3AQ30493563-1F44B052-7C22-4AE5-9D3D-D18B7E15B9EDQ30855883-1803E5D4-2D20-4DA9-9B64-80EC5A5A32E2Q32145030-A4FDC7AC-1121-44C6-BC7F-19595F4C679BQ33256964-6B0D497D-2DF2-4078-81A3-20B9098B9798Q33770602-2FE3F832-A6E5-4B1E-B4EF-DD4F6FEA98C7Q33975709-BDCDED01-5709-4395-B687-ACDB19BBA9DCQ34115950-4688594C-A35D-4C47-BF9B-1C242C89F0D2Q34194481-C1D473C4-1A80-4438-AFAB-E12B46475BC2Q34620197-CC162FF8-8533-425B-B522-8DE5891BB68DQ35634197-02B440D4-4262-463D-A5FA-2DFBE732FF9FQ35846106-E0DD408C-E5C8-4ADA-A54D-A14984A12B65Q35941319-25ED6023-0B27-4F38-966B-BA4C9F9E7AF0Q36459698-10F365E6-F3EE-49DE-BB34-FC42C010CE1CQ37018277-B408B678-F562-410A-B613-7579F1362736Q37093155-D440992B-BDB9-4784-A3A3-C0F94056348CQ37128281-059CC1CF-0357-4A2F-9E94-F574BF961F1AQ37277042-0DCFAF14-52D1-4DF8-BB3A-F460DD43E715Q37476759-7C434728-712B-48B7-864B-A3529928A80AQ37662804-D0DA695E-2A85-44D6-B1D6-F7629B1D95D9Q37767914-6FED1A10-6F46-437A-A210-AE7F440D4366Q38623011-5F3F0FE7-9709-41ED-8A3F-E82A4E4D6FCFQ39812716-5B48CFB9-ED5B-4563-B5F7-8560ABBDBAC8Q40047888-02B0319C-1478-4B8F-AE4B-00D6F719D215Q40108832-8C0E2F77-34B8-4B75-9203-423D42A6248EQ40276593-321462DE-86B7-403A-9E17-0C7D3FEBE1F1Q40582329-0A6FFA98-453C-4794-A116-EE2F888089F2Q40592294-11E626A8-997A-4A50-B0A4-08E46A6B38C5Q41041176-AE6E60A4-91A3-4133-B694-1C4D9A8F52D6Q41100657-92476F2E-D5F1-462A-939F-73896BE450F8Q41597608-CB623343-49A8-4A7F-AD58-24E77C083CF9Q42054639-970AE337-456E-485C-B8AF-8A8B191AC20AQ42622160-FFE6D44B-F4AA-4EE9-9283-603DC8A0EFD5Q42663544-FF673B88-1AE0-4209-8B0D-3593510F95F5
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Craig W Roberts
@nl
Craig W Roberts
@sl
Craig W. Roberts
@en
Craig W. Roberts
@es
type
label
Craig W Roberts
@nl
Craig W Roberts
@sl
Craig W. Roberts
@en
Craig W. Roberts
@es
prefLabel
Craig W Roberts
@nl
Craig W Roberts
@sl
Craig W. Roberts
@en
Craig W. Roberts
@es
P1053
B-8016-2008
P106
P1153
25940305600
57194392900
P21
P2798
P31
P3829
P3835
craig-roberts2
P496
0000-0002-0653-835X