Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase - Test2 - elhamkhani - TriplyDB

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

http://www.wikidata.org/entity/Q27664019

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Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity Structure of the Yersinia pestis FabV Enoyl-ACP Reductase and Its Interaction with Two 2-Pyridone Inhibitors Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii.Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006-2016).Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.Enoyl acyl carrier protein reductase inhibitors: a patent review (2006 - 2010).Antimalarial drugs and drug targets specific to fatty acid metabolic pathway of Plasmodium falciparum.Screening for small molecule inhibitors of Toxoplasma gondii.Acetamides: chemotherapeutic agents for inflammation-associated cancers.Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.Anticancer, anti-inflammatory, and analgesic activities of synthesized 2-(substituted phenoxy) acetamide derivatives.Picolinamides as effective ligands for copper-catalysed aryl ether formation: structure-activity relationships, substrate scope and mechanistic investigations.Selective S-arylation of 2-oxazolidinethiones and selective N-arylation of 2-benzoxazolinones/2-benzimidazolinones.

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Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

http://www.wikidata.org/entity/Q27664019

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2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

@ast

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

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Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

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Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

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type

label

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

@ast

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

@en

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

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Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

@nl

prefLabel

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

@ast

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

@en

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

@en-gb

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

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Journal of Medicinal Chemistry

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Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

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Alan P Kozikowski

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David W Rice

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Ernest J Mui

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Jeffrey Z Lu

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Michael J Kirisits

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Rima L McLeod

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Samuel L Hutson

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Suresh K Tipparaju

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THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

Molecular basis of triclosan activity

Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate

Inhibitor binding studies on enoyl reductase reveal conformational changes related to substrate recognition

Molecular basis for triclosan activity involves a flipping loop in the active site

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)

Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK

Studies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

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6287-300

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scholarly article

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10.1021/JM9017724

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17

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53

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Craig W. Roberts

Fiona L Henriquez

Sergey N Ruzheinikov

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2010-09-09T00:00:00Z

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45602596

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20698542

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Toxoplasma gondii

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2932859

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