about
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effectsHuman ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damagehUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backupHuman AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNAPost-replicative base excision repair in replication fociExcision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylaseCell cycle regulation and in vitro hybrid arrest analysis of the major human uracil-DNA glycosylaseNuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same geneIdentification of a novel, widespread, and functionally important PCNA-binding motifUracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanismsError-free versus mutagenic processing of genomic uracil--relevance to cancerUracil DNA N-glycosylase promotes assembly of human centromere protein ACrystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNAA nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNACell cycle regulation of human DNA repair and chromatin remodeling genesCell cycle regulation and subcellular localization of the major human uracil-DNA glycosylaseCrystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysisAn inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cellsModulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cellsAnalysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologuesNovel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damageHuman and bacterial oxidative demethylases repair alkylation damage in both RNA and DNAProperties and functions of human uracil-DNA glycosylase from the UNG gene.Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.Base excision repair of DNA in mammalian cells.XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damageIdentification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3)mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored.Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3Uracil in DNA--occurrence, consequences and repair.Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Genomic uracil and human disease.Uracil in DNA--general mutagen, but normal intermediate in acquired immunity.Uracil in DNA and its processing by different DNA glycosylasesUracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Atrial myocyte function and Ca2+ handling is associated with inborn aerobic capacity.Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis
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hulumtues
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Geir Slupphaug
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