A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system
about
The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmissionDown-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neuronsThe mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrateInduction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugsAnalysis of alternative splicing associated with aging and neurodegeneration in the human brain.Genome-wide association study of body mass index in 23 000 individuals with and without asthma.Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.IG20/MADD plays a critical role in glucose-induced insulin secretion.DENN domain proteins: regulators of Rab GTPases.Nuclear and cytosolic JNK signalling in neurons.The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells.NF-kappaB activity is induced by neural cell adhesion molecule binding to neurons and astrocytes.MADD is a downstream target of PTEN in triggering apoptosis.DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells.MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells.MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.
P2860
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P2860
A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A splicing variant of a death ...... e human central nervous system
@ast
A splicing variant of a death ...... e human central nervous system
@en
A splicing variant of a death ...... e human central nervous system
@nl
type
label
A splicing variant of a death ...... e human central nervous system
@ast
A splicing variant of a death ...... e human central nervous system
@en
A splicing variant of a death ...... e human central nervous system
@nl
prefLabel
A splicing variant of a death ...... e human central nervous system
@ast
A splicing variant of a death ...... e human central nervous system
@en
A splicing variant of a death ...... e human central nervous system
@nl
P2093
P2860
P356
P1476
A splicing variant of a death ...... e human central nervous system
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.5.2586
P407
P577
1998-03-03T00:00:00Z