Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.
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A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer preventionAMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodentsAn islet in distress: β cell failure in type 2 diabetes.Increased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretionBeta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.The G protein-coupled receptor P2Y14 influences insulin release and smooth muscle function in mice.Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathwayA potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice.CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance.High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions.Glucolipotoxicity in Pancreatic β-Cells.α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion.Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY.Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway.Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs.PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acidsIdentification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptorThe free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetesDiminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.Minor role of mitochondrial respiration for fatty-acid induced insulin secretion.Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRsActivation of GPR40 as a therapeutic target for the treatment of type 2 diabetes.The mechanisms linking adiposopathy to type 2 diabetes.The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretionThe Role and Future of FFA1 as a Therapeutic Target.Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146.Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation.The Pancreatic β-Cell: A Bioenergetic Perspective.
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Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Deletion of GPR40 impairs gluc ...... lar fuel metabolism in islets.
@en
Deletion of GPR40 impairs gluc ...... lar fuel metabolism in islets.
@nl
type
label
Deletion of GPR40 impairs gluc ...... lar fuel metabolism in islets.
@en
Deletion of GPR40 impairs gluc ...... lar fuel metabolism in islets.
@nl
prefLabel
Deletion of GPR40 impairs gluc ...... lar fuel metabolism in islets.
@en
Deletion of GPR40 impairs gluc ...... lar fuel metabolism in islets.
@nl
P2093
P2860
P50
P921
P356
P1433
P1476
Deletion of GPR40 impairs gluc ...... lar fuel metabolism in islets.
@en
P2093
Christina M Sorensen
Marc Prentki
Marie-Line Peyot
Martin G Latour
Richard D Smith
Stephane Gesta
Thomas L Jetton
P2860
P304
P356
10.2337/DB09-0362
P407
P577
2009-08-31T00:00:00Z