Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase.
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Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasomeIntracellular Dynamics of the Ubiquitin-Proteasome-SystemNuclear Import of Yeast ProteasomesThe Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradationAn inducible chaperone adapts proteasome assembly to stress.Proteasome assemblyStructural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitinationUnfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study.Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane.Architecture and assembly of the archaeal Cdc48*20S proteasomeParadigms of protein degradation by the proteasome.Slipping up: partial substrate degradation by ATP-dependent proteases.DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle associationPiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomesRegulated protein turnover: snapshots of the proteasome in action.Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpXBase-CP proteasome can serve as a platform for stepwise lid formationSubstrate degradation by the proteasome: a single-molecule kinetic analysis.N-Terminal Coiled-Coil Structure of ATPase Subunits of 26S Proteasome Is Crucial for Proteasome FunctionGates, Channels, and Switches: Elements of the Proteasome MachineUnique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy.Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasomeUbp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.Substrate Ubiquitination Controls the Unfolding Ability of the Proteasome.A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly.Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.Structural basis for dynamic regulation of the human 26S proteasome.Gyre and gimble in the proteasome.Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine.Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx.The Logic of the 26S Proteasome.The Diverse AAA+ Machines that Repair Inhibited Rubisco Active Sites.Proteasome Structure and Assembly.
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Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase.
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 08 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Reconstitution of the 26S prot ...... metries in its AAA+ unfoldase.
@en
Reconstitution of the 26S prot ...... metries in its AAA+ unfoldase.
@nl
type
label
Reconstitution of the 26S prot ...... metries in its AAA+ unfoldase.
@en
Reconstitution of the 26S prot ...... metries in its AAA+ unfoldase.
@nl
prefLabel
Reconstitution of the 26S prot ...... metries in its AAA+ unfoldase.
@en
Reconstitution of the 26S prot ...... metries in its AAA+ unfoldase.
@nl
P2860
P356
P1476
Reconstitution of the 26S prot ...... metries in its AAA+ unfoldase.
@en
P2093
Eric Estrin
Robyn Beckwith
P2860
P2888
P304
P356
10.1038/NSMB.2659
P577
2013-09-08T00:00:00Z
P5875
P6179
1047728590