The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface.
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RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cellsMolecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapseMechanism and function of Vav1 localisation in TCR signalling.Specific patterns of Cdc42 activity are related to distinct elements of T cell polarizationIntercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses.Recruitment of activation receptors at inhibitory NK cell immune synapsesEffect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation.Imaging T-cell antigen recognition and comparing immunological and neuronal synapses.Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells.Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.Knockout mice: a paradigm shift in modern immunology.T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue.Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance.Visualization of signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.Imaging immune surveillance by T cells and NK cells.Itk: the rheostat of the T cell response.All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton.Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells.Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.TEC-family kinases: regulators of T-helper-cell differentiation.Function of the nucleotide exchange activity of vav1 in T cell development and activation.Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization.Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase CLipid rafts in lymphocyte activation and migration.Tec kinases, actin, and cell adhesion.Rho family GTPases and their regulators in lymphocytes.Age-related defects in the cytoskeleton signaling pathways of CD4 T cells.Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy.Evaluation of Known Defective Signaling-Associated Molecules in Patients Who Primarily Diagnosed as Common Variable Immunodeficiency.Visualization of negative signaling in B cells by quantitative confocal microscopy.Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes.Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation.SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus.Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.The Role of SPECs, Small Cdc42-binding Proteins, in F-actin Accumulation at the Immunological Synapse
P2860
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P2860
The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2000
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The vav exchange factor is an ...... gen-presenting cell interface.
@en
The vav exchange factor is an ...... gen-presenting cell interface.
@nl
type
label
The vav exchange factor is an ...... gen-presenting cell interface.
@en
The vav exchange factor is an ...... gen-presenting cell interface.
@nl
prefLabel
The vav exchange factor is an ...... gen-presenting cell interface.
@en
The vav exchange factor is an ...... gen-presenting cell interface.
@nl
P2093
P2860
P356
P1476
The vav exchange factor is an ...... gen-presenting cell interface.
@en
P2093
P2860
P304
10150-10155
P356
10.1073/PNAS.97.18.10150
P407
P577
2000-08-01T00:00:00Z