vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
about
PairWise and SearchWise: finding the optimal alignment in a simultaneous comparison of a protein profile against all DNA translation frameshSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathwaysIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinasecDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteinsThe human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferationNon-stoichiometric reduced complexity probes for cDNA arraysSmall GTPase RhoG is a key regulator for neurite outgrowth in PC12 cellsVav family proteins couple to diverse cell surface receptorsRegulatory and signaling properties of the Vav familyBinding of Vav to Grb2 through dimerization of Src homology 3 domainsA novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathwaysTyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABLThe SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptorsLoss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potentialMultiple SH2-mediated interactions in v-src-transformed cells.Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frameInteraction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expressionp95vav associates with the nuclear protein Ku-70Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteinsVav2 is required for cell spreadingExpression of the putative proto-oncogene His-1 in normal and neoplastic tissuesSignalling pathways induced by protease-activated receptors and integrins in T cellsVav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancerRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseVav family exchange factors: an integrated regulatory and functional viewP-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironmentsNovel recognition mode between Vav and Grb2 SH3 domainsStructural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in cultureDevelopmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequenceMolecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptorsLck regulates Vav activation of members of the Rho family of GTPasesSpecific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and VavMutation of Vav1 adaptor region reveals a new oncogenic activation.Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.
P2860
Q21061196-0CAEC9E5-DADD-4670-A5F2-CD6B80CE5615Q22009420-B05EBA6D-99DA-4106-A22E-007B3866782DQ24314627-3D1B1F28-FF34-4952-BFFD-2488CAC5EACDQ24321379-DCD4CE0A-BDA4-4894-9029-DD3BB21D92B1Q24337241-E79440A3-250C-43EF-A7C0-24CF36E04183Q24515205-7AAF09F2-2C47-4512-A262-98696CF8E778Q24533574-9724F21B-53D3-486A-8659-A5A8486DBCE3Q24548222-34EC4F32-64E1-4768-8EA9-9A7AAF1AC920Q24551209-8797A665-F5B9-4259-8954-0573446F929DQ24552004-642D7F73-17F2-444B-B5F7-D665D6C7E62BQ24554307-2C8013F8-069A-4369-B25F-044F5BAD5384Q24564126-9446C611-E975-43A9-A777-389C63657631Q24568263-6D4FA397-B51C-44F4-8BD7-C38F1191E539Q24568367-C364FC56-6585-4FE2-AB3A-2A53E7483286Q24600645-259DD6C6-C1FA-4BC2-9B8C-758B3CC63D5DQ24604031-03D036EE-1F92-4135-8EC6-8EE15A08D4EEQ24606832-E09722A9-8F1F-4F38-9412-2612B279301BQ24613990-0AC967E7-0429-4CF7-9974-C3232105C94CQ24649008-1B52921A-0260-4887-B191-BF99360DCC61Q24650938-D6E96A43-CFD8-4B2E-AFF3-5C88147B51D7Q24652816-FDD85649-8BB9-4175-AD9F-96ECA578D312Q24654126-780CD46B-B5A2-46C8-9116-17BAD4201AFCQ24678403-FDAF30C7-2CD3-4E23-9D6F-85C2CACD166AQ24682815-DCBA3267-41A4-4013-ADAD-5C3F51CCA8EEQ26782144-FD076BC4-D431-426D-ADA7-B3C087BA8E21Q26853181-EE55E099-C855-449E-BCC1-CE65164E472CQ27026905-0EB3E3D1-405D-465F-AA16-DD2B76B8D3DCQ27320507-8F314E57-F15B-46D0-91AA-0714A47656BAQ27632592-6F9EE040-3DCB-4440-A713-CC13F5034BDDQ27651005-106D1464-B85A-497F-9E55-4A7F2BE05106Q27659655-37586215-B2B9-43B6-BDB6-3004E8F0FD4AQ27690752-5E0E3883-AB40-4BB9-B632-C49953F77E65Q28576024-D72C3949-B538-4FCF-886C-518437C6A9D6Q28578521-AFF8317F-E9F5-4DC2-B746-C95973C276A7Q28592605-5038706A-0F6E-413B-A2A1-4A1871AF68EEQ28610619-915DCFB9-C25F-49B6-AB98-2D292F39D5E1Q29615971-C3EA5280-5562-480B-8B8B-4341D2124074Q30009278-E268D373-2522-4612-B958-9AEF7ACAF918Q30009890-2D9131B9-F69A-4121-8449-9F13322233C7Q30156866-2C7C8761-8D91-48D0-8A47-EDDA15686B4E
P2860
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
description
1989 nî lūn-bûn
@nan
1989 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@ast
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@en
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@en-gb
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@nl
type
label
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@ast
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@en
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@en-gb
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@nl
prefLabel
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@ast
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@en
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@en-gb
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@nl
P2093
P2860
P1433
P1476
vav, a novel human oncogene de ...... pressed in hematopoietic cells
@en
P2093
D Martin-Zanca
M Barbacid
P2860
P304
P407
P577
1989-08-01T00:00:00Z