Lck regulates Vav activation of members of the Rho family of GTPases - Test2 - elhamkhani - TriplyDB

Lck regulates Vav activation of members of the Rho family of GTPases

Lck regulates Vav activation of members of the Rho family of GTPases

http://www.wikidata.org/entity/Q28610619

about

hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling Crucial structural role for the PH and C1 domains of the Vav1 exchange factor Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins Vav family proteins couple to diverse cell surface receptors Regulatory and signaling properties of the Vav family Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway Vav2 is required for cell spreading The integrin-actin connection, an eternal love affair Signalling pathways induced by protease-activated receptors and integrins in T cells Scambio, a novel guanine nucleotide exchange factor for Rho Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1 Structural basis for a novel interaction between TXNIP and Vav2 AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain Association of the proto-oncogene product dbl with G protein betagamma subunits Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1 PAK1 negatively regulates the activity of the Rho exchange factor NET1 Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells Vav2 is an activator of Cdc42, Rac1, and RhoA Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.

P2860

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P2860

Lck regulates Vav activation of members of the Rho family of GTPases

http://www.wikidata.org/entity/Q28610619

description

1997 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի մարտին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 1997

@ast

im März 1997 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 1997/03/01)

@sk

vědecký článek publikovaný v roce 1997

@cs

wetenschappelijk artikel (gepubliceerd op 1997/03/01)

@nl

наукова стаття, опублікована в березні 1997

@uk

مقالة علمية (نشرت في مارس 1997)

@ar

name

Lck regulates Vav activation of members of the Rho family of GTPases

@ast

Lck regulates Vav activation of members of the Rho family of GTPases

@en

Lck regulates Vav activation of members of the Rho family of GTPases

@nl

type

label

Lck regulates Vav activation of members of the Rho family of GTPases

@ast

Lck regulates Vav activation of members of the Rho family of GTPases

@en

Lck regulates Vav activation of members of the Rho family of GTPases

@nl

prefLabel

Lck regulates Vav activation of members of the Rho family of GTPases

@ast

Lck regulates Vav activation of members of the Rho family of GTPases

@en

Lck regulates Vav activation of members of the Rho family of GTPases

@nl

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Molecular and Cellular Biology

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Lck regulates Vav activation of members of the Rho family of GTPases

@en

P2093

B. Das

http://www.w3.org/2001/XMLSchema#string

C. J. Der

http://www.w3.org/2001/XMLSchema#string

D. Broek

http://www.w3.org/2001/XMLSchema#string

J. Han

http://www.w3.org/2001/XMLSchema#string

J. K. Westwick

http://www.w3.org/2001/XMLSchema#string

L. Van Aelst

http://www.w3.org/2001/XMLSchema#string

R. D. Mosteller

http://www.w3.org/2001/XMLSchema#string

R. Khosravi-Far

http://www.w3.org/2001/XMLSchema#string

W. Wei

http://www.w3.org/2001/XMLSchema#string

P2860

DNA sequencing with chain-terminating inhibitors

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins.

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

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1346–1353

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scholarly article

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3345453

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10.1128/MCB.17.3.1346

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3

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17

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1997-03-01T00:00:00Z

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14178650

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9032261

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231859

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