Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes.
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Roles of microRNAs and long-noncoding RNAs in human immunodeficiency virus replicationTranscriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureNUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoterPhosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytesT-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.Transcriptional and posttranscriptional regulation of HIV-1 gene expressionEpstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomasShort chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia.Subversion of Cell Cycle Regulatory Mechanisms by HIV.Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.MD simulation of the Tat/Cyclin T1/CDK9 complex revealing the hidden catalytic cavity within the CDK9 molecule upon Tat binding.Short Communication: The Broad-Spectrum Histone Deacetylase Inhibitors Vorinostat and Panobinostat Activate Latent HIV in CD4(+) T Cells In Part Through Phosphorylation of the T-Loop of the CDK9 Subunit of P-TEFb.Serum cyclin-dependent kinase 9 is a potential biomarker of atherosclerotic inflammation.CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation.The control of HIV transcription: keeping RNA polymerase II on trackControl of HIV latency by epigenetic and non-epigenetic mechanisms.Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.Lost in transcription: molecular mechanisms that control HIV latencyReactivation of latent HIV: do all roads go through P-TEFb?Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription.Cyclin-dependent kinases as therapeutic targets for HIV-1 infection.Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV.The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies.Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function.P-TEFb as a target to reactivate latent HIV: two Brds are now in hand.Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells.Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression.Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway.BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency.Proteomic Profiling of a Primary CD4+ T Cell Model of HIV-1 Latency Identifies Proteins Whose Differential Expression Correlates with Reactivation of Latent HIV-1.Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
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Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4
@nl
Characterization of Cdk9 T-loo ...... ctivated CD4(+) T lymphocytes.
@en
type
label
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4
@nl
Characterization of Cdk9 T-loo ...... ctivated CD4(+) T lymphocytes.
@en
prefLabel
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4
@nl
Characterization of Cdk9 T-loo ...... ctivated CD4(+) T lymphocytes.
@en
P2860
P356
P1476
Characterization of Cdk9 T-loo ...... activated CD4(+) T lymphocytes
@en
P2093
Eugene C Dow
Rajesh Ramakrishnan
P2860
P304
P356
10.1189/JLB.0509309
P577
2009-09-10T00:00:00Z