The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.
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Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactionsCoexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level.Making sense of G-quadruplex and i-motif functions in oncogene promoters.Folding and hydrodynamics of a DNA i-motif from the c-MYC promoter determined by fluorescent cytidine analogs.Intramolecular folding in human ILPR fragment with three C-rich repeatsReplication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract.DNA acting like RNA.The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements.Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1Molecular classification, pathway addiction, and therapeutic targeting in diffuse large B cell lymphomaAnti-sense DNA d(GGCCCC)n expansions in C9ORF72 form i-motifs and protonated hairpins.GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules.The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.Conformational changes of non-B DNA.Reversible conformational switching of i-motif DNA studied by fluorescence spectroscopy.Fluorescent probes for G-quadruplex structures.Targeting non-B-form DNA in living cells.Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif.Nucleic Acid i-Motif Structures in Analytical Chemistry.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Identification of multiple genomic DNA sequences which form i-motif structures at neutral pHDistance-dependent duplex DNA destabilization proximal to G-quadruplex/i-motif sequences.The importance of loop length on the stability of i-motif structures.Proton-bound dimers of 1-methylcytosine and its derivatives: vibrational and NMR spectroscopy.Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.2'-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA.Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids.Stabilization of Telomeric I-Motif Structures by (2'S)-2'-Deoxy-2'-C-Methylcytidine Residues.Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks.In-stem thiazole orange reveals the same triplex intermediate for pH and thermal unfolding of i-motifs.Improved i-motif thermal stability by insertion of anthraquinone monomers.Dual-stimuli responsive i-motif/nanoflares for sensing ATP in lysosomes.Ruthenium (II) polypyridyl complexes stabilize the bcl-2 promoter quadruplex and induce apoptosis of Hela tumor cells.Tuning the pH Response of i-Motif DNA OligonucleotidesFundamental aspects of the nucleic acid i-motif structuresRapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promotersi-Motif DNA: structural features and significance to cell biology
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P2860
The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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The i-motif in the bcl-2 P1 pr ...... ue 8:5:7 loop folding pattern.
@en
The i-motif in the bcl-2 P1 pr ...... ue 8:5:7 loop folding pattern.
@nl
type
label
The i-motif in the bcl-2 P1 pr ...... ue 8:5:7 loop folding pattern.
@en
The i-motif in the bcl-2 P1 pr ...... ue 8:5:7 loop folding pattern.
@nl
prefLabel
The i-motif in the bcl-2 P1 pr ...... ue 8:5:7 loop folding pattern.
@en
The i-motif in the bcl-2 P1 pr ...... ue 8:5:7 loop folding pattern.
@nl
P2093
P2860
P356
P1476
The i-motif in the bcl-2 P1 pr ...... ue 8:5:7 loop folding pattern.
@en
P2093
Laurence H Hurley
Samantha Kendrick
Sidney M Hecht
Yoshitsugu Akiyama
P2860
P304
17667-17676
P356
10.1021/JA9076292
P407
P577
2009-12-01T00:00:00Z