Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

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The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis.

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Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

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artigo científico

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bilimsel makale

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scientific article published on 30 June 2016

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Amino acid-dependent signaling ...... gulation of rDNA transcription

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Amino acid-dependent signaling ...... ulation of rDNA transcription.

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Amino acid-dependent signaling ...... gulation of rDNA transcription

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Amino acid-dependent signaling ...... ulation of rDNA transcription.

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Amino acid-dependent signaling ...... gulation of rDNA transcription

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Amino acid-dependent signaling ...... ulation of rDNA transcription.

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Amino acid-dependent signaling ...... gulation of rDNA transcription

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Allison J Ogden

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Eric P Kusnadi

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Jian Kang

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Katherine M Hannan

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Lukas Bammert

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Sandy Hung

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Ulrike Kutay

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.

hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters

The nucleolus under stress

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

The selectivity of protein kinase inhibitors: a further update

Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

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48887-48904

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scholarly article

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10.18632/ONCOTARGET.10346

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English

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2016-06-30T00:00:00Z

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27385002

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5226478

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Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

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Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932