FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
about
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal CancerIdelalisib induces PUMA-dependent apoptosis in colon cancer cells.Ubiquitin ligases in oncogenic transformation and cancer therapy.Significance of the E3 ubiquitin protein UBR5 as an oncogene and a prognostic biomarker in colorectal cancer.NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction.Hsp90 inhibitor sensitizes TRAIL-mediated apoptosis via chop-dependent DR5 upregulation in colon cancer cells.BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922.PUMA mediates the anti-cancer effect of osimertinib in colon cancer cells.Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer.FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells.Physiological functions of FBW7 in cancer and metabolism.Antiapoptotic BCL-2 proteins determine sorafenib/regorafenib resistance and BH3-mimetic efficacy in hepatocellular carcinoma.miR-206 regulates 5-FU resistance by targeting Bcl-2 in colon cancer cells.Dasatinib promotes TRAIL-mediated apoptosis by upregulating CHOP-dependent death receptor 5 in gastric cancer.The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine.MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/β-catenin pathway.F-box proteins involved in cancer-associated drug resistance.FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro.Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systemsMEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells
P2860
Q33817695-0AE0CBD7-491E-4612-A0E3-1C230D2AF758Q37701548-0E6D6BD9-43DD-436C-AAC9-3F21C05DE2B2Q46609299-54527C39-48BC-42C5-A56C-BC11D6C66500Q47128996-E677A0B9-6A86-4514-BEE4-110B2E3603E2Q47141630-67F93B9A-520E-4BDE-8ACD-0832BE572A8FQ47161019-705D6A1E-04FB-4100-BF71-CFEBB1DC4AE6Q47606169-01F81EFA-E92E-403B-AD72-C783D46573F2Q49350552-5AA2C7A9-0EFD-402F-AFB0-01104F16D38CQ50026061-E3833E24-6843-4B5E-9DE3-29D795EA686EQ50942181-090058CE-7BDE-4DF7-9EE8-9B85A4AEA983Q51136478-DBDD5969-12A9-4801-B284-D77CF255A9E6Q52374099-D13D2FBB-4A2A-4D87-967E-CBCBDD6B2644Q52571263-AAB48245-A12B-4114-8CCB-7C4A8D6F700CQ52595282-61153FD5-D67A-430B-A29A-A8CD45A358BCQ54111073-28F23676-572F-4143-B4EB-BD3FC1143473Q55098659-58563D3D-6703-47F0-9CA2-8E0A333F33CDQ55209609-FCED2AC8-B9AD-473A-995F-5E0B5777835DQ55253244-32BFB95C-6450-435B-9E7F-94A886AB1F1DQ55258442-494D8469-BDDE-49A1-A01A-15CAF63E35D9Q55411157-573579CD-2CC0-4B5E-B821-8521FD80F629Q55478389-9D2751BE-9102-48DF-9A51-47C0A1DB8D53Q58603251-1CBC77F6-B982-4BD1-B889-DC88EBEE8102Q58760429-4A3C3A5B-73C3-4C59-A1E6-6815A85AD938
P2860
FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 July 2016
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
FBW7 mutations mediate resista ...... by blocking Mcl-1 degradation.
@en
FBW7 mutations mediate resista ...... by blocking Mcl-1 degradation.
@nl
type
label
FBW7 mutations mediate resista ...... by blocking Mcl-1 degradation.
@en
FBW7 mutations mediate resista ...... by blocking Mcl-1 degradation.
@nl
prefLabel
FBW7 mutations mediate resista ...... by blocking Mcl-1 degradation.
@en
FBW7 mutations mediate resista ...... by blocking Mcl-1 degradation.
@nl
P2860
P50
P356
P1433
P1476
FBW7 mutations mediate resista ...... by blocking Mcl-1 degradation
@en
P2860
P2888
P304
P356
10.1038/ONC.2016.247
P407
P577
2016-07-11T00:00:00Z