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IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cellsPUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cellsPUMA mediates the apoptotic response to p53 in colorectal cancer cellsPUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndromeA simplified system for generating recombinant adenovirusesSMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial eventsSmac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathwayAurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells.Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis.PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cellsFibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice.PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.A cell-penetrating peptide suppresses inflammation by inhibiting NF-κB signalingPharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiationInhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growthInvestigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model.mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens.Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway.Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice.BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cellsFBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.Role of Smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma.Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis.ADAR1 is essential for intestinal homeostasis and stem cell maintenance.Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.
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description
researcher ORCID: 0000-0002-4021-1000
@en
name
Jian Yu
@ast
Jian Yu
@en
Jian Yu
@nl
Jian Yu
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type
label
Jian Yu
@ast
Jian Yu
@en
Jian Yu
@nl
Jian Yu
@sl
prefLabel
Jian Yu
@ast
Jian Yu
@en
Jian Yu
@nl
Jian Yu
@sl
P106
P31
P496
0000-0002-4021-1000