Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.
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Bidirectional regulation of Aβ levels by Presenilin 1.Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's diseasePresenilin-1 mutations and Alzheimer's disease.Re-imagining Alzheimer's disease - the diminishing importance of amyloid and a glimpse of what lies ahead.Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.Untangling Genetic Risk for Alzheimer's Disease.CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer's Disease Skin Fibroblasts.Influence of solubilization and AD-mutations on stability and structure of human presenilins.Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.Allosteric Modulation of Intact γ-Secretase Structural Dynamics.The role of astrocytes in amyloid production and Alzheimer's disease.Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease.Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer.PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease.Dominant negative mechanism of Presenilin-1 mutations in FAD.A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.The genes associated with early-onset Alzheimer's disease.The Role of Genetics in Advancing Precision Medicine for Alzheimer's Disease-A Narrative Review.Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's diseaseRole of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration inDysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease
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P2860
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 December 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Analysis of 138 pathogenic mut ...... Aβ40 peptides by γ-secretase.
@en
Analysis of 138 pathogenic mut ...... Aβ40 peptides by γ-secretase.
@nl
type
label
Analysis of 138 pathogenic mut ...... Aβ40 peptides by γ-secretase.
@en
Analysis of 138 pathogenic mut ...... Aβ40 peptides by γ-secretase.
@nl
prefLabel
Analysis of 138 pathogenic mut ...... Aβ40 peptides by γ-secretase.
@en
Analysis of 138 pathogenic mut ...... Aβ40 peptides by γ-secretase.
@nl
P2093
P2860
P356
P1476
Analysis of 138 pathogenic mut ...... Aβ40 peptides by γ-secretase.
@en
P2093
Guanghui Yang
Linfeng Sun
Yigong Shi
P2860
P304
P356
10.1073/PNAS.1618657114
P407
P577
2016-12-05T00:00:00Z