Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
about
The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteinsPresenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationFamilial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levelsA protease-independent function for SPPL3 in NFAT activationA polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease riskTMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for SpermatogenesisRole of presenilin 1 in structural plasticity of cortical dendritic spines in vivoMitochondria, calcium and cell death: a deadly triad in neurodegenerationPresenilins are essential for regulating neurotransmitter releaseSpecific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cellsAn EF hand mutation in Stim1 causes premature platelet activation and bleeding in miceSynaptic function of nicastrin in hippocampal neuronsConditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationNew and notable ion-channels in the sarcoplasmic/endoplasmic reticulum: do they support the process of intracellular Ca(2+) release?Neuronal endoplasmic reticulum stress in axon injury and neurodegenerationFK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degenerationToward the structure of presenilin/γ-secretase and presenilin homologsEarly etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's diseaseLysosome and calcium dysregulation in Alzheimer's disease: partners in crimeAnalyzing dendritic spine pathology in Alzheimer's disease: problems and opportunitiesProtein transamidation by transglutaminase 2 in cells: a disputed Ca2+-dependent action of a multifunctional proteinA C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysisMolecular profiling reveals diversity of stress signal transduction cascades in highly penetrant Alzheimer's disease human skin fibroblastsDevelopment and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's diseaseA novel calcium-binding protein is associated with tau proteins in tauopathyAmyloid oligomer neurotoxicity, calcium dysregulation, and lipid raftsHaploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoStructural basis of human γ-secretase assembly.Receptor activated Ca(2+) release is inhibited by boric acid in prostate cancer cells.Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.A novel function for the presenilin family member spe-4: inhibition of spermatid activation in Caenorhabditis elegansMitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDsIntracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin.Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.
P2860
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P2860
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@ast
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@en
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@en-gb
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@nl
type
label
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@ast
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@en
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@en-gb
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@nl
prefLabel
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@ast
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@en
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@en-gb
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@nl
P2093
P2860
P921
P3181
P1433
P1476
Presenilins form ER Ca2+ leak ...... mer's disease-linked mutations
@en
P2093
Arseny Bezprozvanny
Huiping Tu
Ilya Bezprozvanny
Lutgarde Serneels
Omar Nelson
Sheu-Fen Lee
Yi-Heng Hao
Zhengnan Wang
P2860
P304
P3181
P356
10.1016/J.CELL.2006.06.059
P407
P577
2006-09-08T00:00:00Z