Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
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Recent advances in the biology and drug targeting of malaria parasite aminoacyl-tRNA synthetasesEvolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode ClassificationtRNAs as antibiotic targetsStructural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporinStructural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetaseDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsA genomic and evolutionary approach reveals non-genetic drug resistance in malariaPlasmodium falciparum mitochondria import tRNAs along with an active phenylalanyl-tRNA synthetaseThe complex evolutionary history of aminoacyl-tRNA synthetases.Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.A Quantitative Spectrophotometric Assay to Monitor the tRNA-Dependent Pathway for Lipid Aminoacylation In Vitro.Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.Essential proteins and possible therapeutic targets of Wolbachia endosymbiont and development of FiloBase--a comprehensive drug target database for Lymphatic filariasis.Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.Drug discovery: Chemical diversity targets malaria.Genetic Validation of Leishmania donovani Lysyl-tRNA Synthetase Shows that It Is Indispensable for Parasite Growth and Infectivity.Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.A continuous assay for monitoring the synthetic and proofreading activities of multiple aminoacyl-tRNA synthetases for high-throughput drug discovery.Drugging tRNA aminoacylation.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one.Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases.Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target.Current Screening Methodologies in Drug Discovery for Selected Human Diseases
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P2860
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
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2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
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2013年學術文章
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name
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
@en
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
@nl
type
label
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
@en
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
@nl
prefLabel
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
@en
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
@nl
P2093
P2860
P50
P1476
Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.
@en
P2093
Erin E Lim
James S Pham
Karen L Dawson
Katherine E Jackson
P2860
P356
10.1016/J.IJPDDR.2013.10.001
P577
2013-11-11T00:00:00Z