Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate. - Test2 - elhamkhani - TriplyDB

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.

http://www.wikidata.org/entity/Q37625209

about

New Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in Plasmodium Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin Newer patents in antimycobacterial therapy.DXS as a target for structure-based drug design.Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor.Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.

P2860

Q28078674-3EE2307B-7FD7-41D1-BF4B-9AF4C97BF3E9 Q28542677-E3139F5A-BA99-4093-8F14-589A985A86D5 Q30043334-45F9F345-A3EB-452F-8DD4-B0BBD71B63D9 Q35691316-C62ADF7F-88BA-4A79-AFB6-7000E3E1B0B0 Q36854802-7CA9EC56-A823-4580-9EA7-CBD2ABCD3829 Q38510495-311EC5DA-8609-4D92-B6D6-037C1B732201 Q38668515-32859E0A-5370-4E5B-8AB8-2ACC25FAC22A Q40163906-946596A3-F5B6-46E7-AAFC-1DF558497BEF Q40495245-145F8665-3AD4-43BE-898A-6D03703E2A04 Q40995448-314189B4-E018-4D02-B77F-66FB7A82B2A7 Q48241056-2FE33E83-52BD-494F-8241-F2C645B8D723 Q48336041-3236D44B-B415-46B3-912D-19F00169262F Q55093817-BD98BD88-FC6F-4B61-A651-7A409A091FD7

P2860

Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.

http://www.wikidata.org/entity/Q37625209

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 30 October 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Targeting DXP synthase in huma ...... ity of butylacetylphosphonate.

@en

Targeting DXP synthase in huma ...... ity of butylacetylphosphonate.

@nl

type

label

Targeting DXP synthase in huma ...... ity of butylacetylphosphonate.

@en

Targeting DXP synthase in huma ...... ity of butylacetylphosphonate.

@nl

prefLabel

Targeting DXP synthase in huma ...... ity of butylacetylphosphonate.

@en

Targeting DXP synthase in huma ...... ity of butylacetylphosphonate.

@nl

P1433

Q37625209-5C497B9A-3858-45D6-A5AA-F41812DF7678

P1476

Q37625209-A03084CE-5F42-4A6B-8039-F587BBF66AEE

P2093

Q37625209-77E94C2B-F713-41A3-A5AF-3FA9C0D26AC7

Q37625209-7E3395FD-52E0-4ADC-8A62-1887C7991383

Q37625209-D5548D6A-DD18-4070-ADD1-14CCA72E38A3

Q37625209-D7EDAB88-51AC-41CC-8653-7ECA63E83806

Q37625209-DF8BEC08-AE1A-4271-AA3D-D1E1BE6434A5

P2860

Q37625209-079CFF11-F825-4470-AD0D-940CC2E2D56F

Q37625209-09035E54-3F47-4AA6-BAEC-775BFB0A13BE

Q37625209-0BCD516E-DB46-4ED3-8D64-5C3C3546BB02

Q37625209-0E12C75C-8A24-4ED5-A6B7-A3F1687653D0

Q37625209-142A5F8A-C1CE-4BF6-A127-DABE5D2823BF

Q37625209-142CBDA1-51D3-4445-A2D1-EFA38DD8651C

Q37625209-181FDC8F-2685-4A97-8A8C-988C1F318A53

Q37625209-1BBC6167-888E-4529-8D48-2275B4A3AEC7

Q37625209-271EFD7B-0E5C-4335-8942-8F8BF18C67CA

Q37625209-282346BD-AB21-4A3E-973A-F7F72AF78C7D

P2888

Q37625209-A12F9DAD-61CE-4F35-8B42-C63FF38F07DE

P304

Q37625209-67598368-87B1-4902-A8A0-8D3C5A5E69F0

P31

Q37625209-26040DB3-E62A-425C-8EDC-B75D352AB12D

P356

Q37625209-2D95BD3C-88A7-4C5F-9C03-CD04B2FB6ECD

P433

Q37625209-CCB756BB-63F2-4499-A423-EAA6A5D44061

P478

Q37625209-CB5725B0-D66B-477C-A591-8A4570D968D3

P50

Q37625209-3932AA94-12BD-489C-9533-F5C8FFB2A805

Q37625209-588B455B-1FC0-4982-ACC5-B7B146A21B65

P577

Q37625209-AE811980-06AD-4BA9-8F31-BDF05EAEFE7B

P5875

Q37625209-323E47DD-5E9C-4AEE-BE5B-A649FBD17D65

P6179

Q37625209-5E6949D4-ABF9-4B48-9544-AE45EB260A96

P698

Q37625209-8DD4FFAE-B1F4-4183-A1A8-4877D047CB7A

P932

Q37625209-0C2590BB-A0EE-4D4D-AA7A-76C2512B4B34

P356

P1433

The Journal of Antibiotics

P1476

Targeting DXP synthase in huma ...... ity of butylacetylphosphonate.

@en

P2093

Jessica M Smith

http://www.w3.org/2001/XMLSchema#string

Misty L Kuhn

http://www.w3.org/2001/XMLSchema#string

Nicole V Warrington

http://www.w3.org/2001/XMLSchema#string

Ryan J Vierling

http://www.w3.org/2001/XMLSchema#string

Wayne F Anderson

http://www.w3.org/2001/XMLSchema#string

P2860

Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)

Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component

Antibacterial drug leads targeting isoprenoid biosynthesis

Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy

Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase

The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs

Discovery and biological characterization of geranylated RNA in bacteria

P2888

P304

77-83

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/JA.2013.105

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

67

http://www.w3.org/2001/XMLSchema#string

P50

Andrew T Koppisch

Caren L Freel Meyers

P577

2013-10-30T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

258147513

http://www.w3.org/2001/XMLSchema#string

P6179

1022501010

http://www.w3.org/2001/XMLSchema#string

P698

24169798

http://www.w3.org/2001/XMLSchema#string

P932

3946878

http://www.w3.org/2001/XMLSchema#string