UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
about
Zebrafish: an important tool for liver disease researchIdentification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in ZebrafishDNA methylation, its mediators and genome integrityZebrafish as a disease model for studying human hepatocellular carcinomaMBD4 interacts with and recruits USP7 to heterochromatic fociActivating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafishOverexpression of UHRF1 gene correlates with the major clinicopathological parameters in urinary bladder cancer.Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells.Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Functional dissection of the role of UHRF1 in the regulation of retinoblastoma methylome.Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1.DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryosEpigenetic control of intestinal barrier function and inflammation in zebrafish.H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiationEstablishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication, transcription and chromatin remodeling.An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancerRegulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis.Elevated expression of UHRF1 predicts unfavorable prognosis for patients with hepatocellular carcinoma.Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma.UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.High-fat diet intake from senescence inhibits the attenuation of cell functions and the degeneration of villi with aging in the small intestine, and inhibits the attenuation of lipid absorption ability in SAMP8 mice.E2F8 as a Novel Therapeutic Target for Lung CancerA Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In VitroDevelopment of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras V12 expression in transgenic zebrafish.A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choiceUHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomyUHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development.Radiation-induced changes in DNA methylation of repetitive elements in the mouse heartNegative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.Comparative Epigenomic Profiling of the DNA Methylome in Mouse and Zebrafish Uncovers High Interspecies DivergenceAntiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells.Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes.UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma.Zebrafish Discoveries in Cancer Epigenetics.Elevated UHRF1 expression contributes to poor prognosis by promoting cell proliferation and metastasis in hepatocellular carcinoma.CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1.
P2860
Q26796338-E5AC1B7D-F1CB-4414-942F-232912AC71E1Q27310913-082EF7E7-4511-4B65-BB90-01649A327E29Q28080760-8C8D8CC7-5212-4F07-AA5A-71960E8172D0Q28081542-30F43169-13A5-4F4D-A8BE-4B132E2C4B84Q28250621-0D621736-8B24-41A0-98EB-7A9B1AD4DD26Q28539163-CC72C00A-CC55-49A0-936C-F1AAE7F11C20Q33692622-11AEDE51-4890-4955-9D17-B329260DC535Q33765984-BE423BBA-8720-423E-9A63-ECBEFCA5BA31Q33814223-B2F405B3-D9FB-4729-8A4A-B63D35CC2FFCQ33889243-999909D3-3774-4EB0-A8BA-6B7555659902Q34278046-3B18E10C-F725-4230-A51A-A4910777BFCAQ34999653-EBEE5B67-D921-4D3B-900F-E4D855E5DF97Q35156930-A722B2AE-EA5A-4F1B-A1EF-8ECF7E530A4AQ35476312-0F6011BF-E49F-4C44-87BA-88EF8B51DEC8Q35560360-5844428A-C4D0-4491-BA73-EF8D22732AE2Q35832884-B4973602-BBDC-4AB3-8406-6279E30B8005Q35848254-58552550-AB5A-4E92-9785-16E0D1600AE7Q35904200-F7C57FCC-1936-400E-AD6A-F913D942F345Q36095316-096273E5-C952-4246-AEA2-63A4620E9156Q36126047-2853152D-0F1D-404C-88EB-8A40DCEB77C9Q36206457-75221F98-BFE7-441E-913F-D327A5331AF7Q36211327-05400AE2-F940-44AC-8385-7B4CDED574D4Q36265374-A2966B7A-6154-4E32-9186-114A2AE5DE35Q36294944-8D0B9169-BD41-41B4-804D-D95CD48C26EDQ36394208-F72C3609-A0CD-4660-A848-D98FB65B7006Q36501027-7206C4D6-5707-4525-8EED-68F9E7C5EFE4Q36506865-63C004DD-E603-44DA-B4FA-BA824F4EEA0AQ36587931-3FF46D40-CC70-45C6-82E1-6F994AB055D2Q36746439-D9027B27-0C42-4987-87A8-042DE3559584Q36788582-2F03210C-6E27-4AA3-8430-BA4D4F13164EQ36848353-9B43F3F8-7372-49D6-9AB8-CFCE4A28504BQ37014343-60A3DD30-B51C-4C9D-9233-1FC27B66708CQ37014980-CEC572D0-9044-4A49-98C6-62CF17DA7BD7Q37076868-8CBBB912-6CFB-4801-8B31-F27439A855C4Q37589996-C8AE8568-8E46-45BC-A504-30F8B7A79961Q37628934-8AE16BB4-7FED-498C-969E-63425C59417BQ37651410-93A2AA9E-4459-440E-9FF7-21352E67BA24Q37705867-C8138E26-67C0-45EA-8C3E-F92CDC8436D9Q37718344-B363BCEE-B49A-4B87-B50F-CA71476DB4C9Q37745546-ADB05E78-661D-49F4-BE26-E434213E6B2B
P2860
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 January 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
@en
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.
@nl
type
label
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
@en
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.
@nl
prefLabel
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
@en
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.
@nl
P2093
P2860
P50
P1433
P1476
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
@en
P2093
Anal Desai
Anja Lachenmayer
Chinweike Ukomadu
Clara Alsinet
Kate Revill
Kensuke Kojima
Kirsten C Sadler
M Isabel Fiel
Raksha Mudbhary
Ravi Sachidanandam
P2860
P304
P356
10.1016/J.CCR.2014.01.003
P577
2014-01-30T00:00:00Z