WWOX gene and gene product: tumor suppression through specific protein interactions. - Test2 - elhamkhani - TriplyDB

WWOX gene and gene product: tumor suppression through specific protein interactions.

WWOX gene and gene product: tumor suppression through specific protein interactions.

http://www.wikidata.org/entity/Q37690302

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Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells Wwox-Brca1 interaction: role in DNA repair pathway choice The noncanonical NF-κB pathway.WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.WWOX suppresses KLF5 expression and breast cancer cell growth WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene.WWOX expression in colorectal cancer--a real-time quantitative RT-PCR study.Loss of wwox expression in zebrafish embryos causes edema and alters Ca(2+) dynamics The WWOX gene modulates high-density lipoprotein and lipid metabolism.The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding WW domain-containing oxidoreductase in neuronal injury and neurological diseases.Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.Role of WWOX and NF-κB in lung cancer progression WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use.Alteration of WWOX in human cancer: a clinical view.Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma.Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer.A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells.Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.WW domain interactions regulate the Hippo tumor suppressor pathway.Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma.WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications.The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability.The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism.Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation.WW domain containing oxidoreductase induces apoptosis in gallbladder-derived malignant cell by upregulating expression of P73 and PUMA.Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy Characterization of WWOX inactivation in murine mammary gland development.WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer.Wwox inactivation enhances mammary tumorigenesis.WWOX modulates the ATR-mediated DNA damage checkpoint response Characterization of substrate binding of the WW domains in human WWP2 protein.NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.Reduced WWOX protein expression in human astrocytoma.The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations.Whole exome sequencing identified genetic variations in Chinese hemangioblastoma patients.Association between WWOX and the risk of malignant tumor, especially among Asians: evidence from a meta-analysis.

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P2860

WWOX gene and gene product: tumor suppression through specific protein interactions.

http://www.wikidata.org/entity/Q37690302

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on February 2010

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

WWOX gene and gene product: tumor suppression through specific protein interactions.

@en

WWOX gene and gene product: tumor suppression through specific protein interactions.

@nl

type

label

WWOX gene and gene product: tumor suppression through specific protein interactions.

@en

WWOX gene and gene product: tumor suppression through specific protein interactions.

@nl

prefLabel

WWOX gene and gene product: tumor suppression through specific protein interactions.

@en

WWOX gene and gene product: tumor suppression through specific protein interactions.

@nl

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Future Oncology

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WWOX gene and gene product: tumor suppression through specific protein interactions.

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Kay Huebner

http://www.w3.org/2001/XMLSchema#string

Rami Aqeilan

http://www.w3.org/2001/XMLSchema#string

Zaidoun Salah

http://www.w3.org/2001/XMLSchema#string

P2860

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2.

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma

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249-259

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scholarly article

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10.2217/FON.09.152

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2

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6

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2010-02-01T00:00:00Z

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41420971

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20146584

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2832309

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