DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
about
A functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells.TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint.DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP.Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling.Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances In Vitro and In Vivo Cytotoxicity in Head and Neck Squamous Cell Carcinoma.USP7 controls Chk1 protein stability by direct deubiquitination.Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance.EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair.PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway.The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.
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DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
DNA-PKcs is required to mainta ...... al replication stress response
@en
DNA-PKcs is required to mainta ...... l replication stress response.
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type
label
DNA-PKcs is required to mainta ...... al replication stress response
@en
DNA-PKcs is required to mainta ...... l replication stress response.
@nl
prefLabel
DNA-PKcs is required to mainta ...... al replication stress response
@en
DNA-PKcs is required to mainta ...... l replication stress response.
@nl
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DNA-PKcs is required to mainta ...... al replication stress response
@en
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Benjamin Pc Chen
Hung-Ying Shih
Shinji Matsunaga
Yu-Fen Lin
Zengfu Shang
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P304
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10.1093/NAR/GKU116
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P577
2014-02-05T00:00:00Z