Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes - Test2 - elhamkhani - TriplyDB

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

http://www.wikidata.org/entity/Q24533892

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Human single-stranded DNA binding proteins are essential for maintaining genomic stability Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53 A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination Metnase promotes restart and repair of stalled and collapsed replication forks DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK Human CtIP promotes DNA end resection Effects of camptothecin on double-strand break repair by non-homologous end-joining in DNA mismatch repair-deficient human colorectal cancer cell lines South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response Human CtIP mediates cell cycle control of DNA end resection and double strand break repair Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex 53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage Regulation of DNA double-strand break repair pathway choice Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.Identification and characterization of SMARCAL1 protein complexes Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma Involvement of DNA-dependent protein kinase in UV-induced replication arrest.DNA replication but not nucleotide excision repair is required for UVC-induced replication protein A phosphorylation in mammalian cells UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair.The majority of human replication protein A remains complexed throughout the cell cycle.The phosphorylation domain of the 32-kDa subunit of replication protein A (RPA) modulates RPA-DNA interactions. Evidence for an intersubunit interaction.Etoposide induces the dispersal of DNA ligase I from replication factories Replication protein A (RPA) phosphorylation prevents RPA association with replication centers.DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respo Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.

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Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

http://www.wikidata.org/entity/Q24533892

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1999 nî lūn-bûn

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1999 թվականի մարտին հրատարակված գիտական հոդված

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Replication-mediated DNA damag ...... ssociates RPA:DNA-PK complexes

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Replication-mediated DNA damag ...... ssociates RPA:DNA-PK complexes

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Replication-mediated DNA damag ...... ssociates RPA:DNA-PK complexes

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Replication-mediated DNA damag ...... ssociates RPA:DNA-PK complexes

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C X Cao

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H Zhang

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P2860

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner.

Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex.

Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity.

DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA

An interaction between replication protein A and SV40 T antigen appears essential for primosome assembly during SV40 DNA replication.

Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA.

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies.

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1397-406

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1714913

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10.1093/EMBOJ/18.5.1397

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5

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13225266

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10064605

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phosphorylation

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1171229

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