Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase.
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Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogasterHYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer ResponseLITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growthDrosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species.Zfra is a small wizard in the mitochondrial apoptosismiR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene.WW domain-containing oxidoreductase in neuronal injury and neurological diseases.Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia.Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain.Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo.Emerging roles for hyaluronidase in cancer metastasis and therapy.HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cellsTIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell deathRole of WWOX and NF-κB in lung cancer progressionTumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas.Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma.Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductaseWWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis.The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed.The fragile site WWOX gene and the developing brain.Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors.Zfra induction of memory anticancer response via a novel immune cellRole of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation.Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation.Reduced WWOX protein expression in human astrocytoma.Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events.WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.WWOX Phosphorylation, Signaling, and Role in Neurodegeneration
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Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 June 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Signaling from membrane recept ...... ain-containing oxidoreductase.
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Signaling from membrane recept ...... ain-containing oxidoreductase.
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Signaling from membrane recept ...... ain-containing oxidoreductase.
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Signaling from membrane recept ...... ain-containing oxidoreductase.
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prefLabel
Signaling from membrane recept ...... ain-containing oxidoreductase.
@en
Signaling from membrane recept ...... ain-containing oxidoreductase.
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P2093
P2860
P356
P1476
Signaling from membrane recept ...... ain-containing oxidoreductase.
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P2093
Feng-Jie Lai
Hsin-Ping Lin
Jean-Yun Chang
Li-Jin Hsu
Nan-Shan Chang
Qunying Hong
Ruei-Yu He
Shean-Jen Chen
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P304
P356
10.1258/EBM.2010.009351
P577
2010-06-11T00:00:00Z