about
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting proteinQuantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's diseaseSortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.Sortilin is essential for proNGF-induced neuronal cell deathSORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processesNeuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICINEvidence for an essential role of megalin in transepithelial transport of retinolA two-receptor pathway for catabolism of Clara cell secretory protein in the kidneySortilin: a receptor to regulate neuronal viability and functionSortilin mediates vascular calcification via its recruitment into extracellular vesiclesSort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein exportMolecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated proteinMolecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatographyHyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulinSorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral gliaSortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinctionFunctional organization of the sortilin Vps10p domain.Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease.Lipoprotein receptors: new roles for ancient proteins.A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.Role of endocytosis in cellular uptake of sex steroids.Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.Megalin knockout mice as an animal model of low molecular weight proteinuria.Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosisVPS10P-domain receptors - regulators of neuronal viability and function.Sortilins: new players in lipoprotein metabolism.Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).Pro-neurotrophins, sortilin, and nociception.Sortilins in neurotrophic factor signaling.Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.Structure of heparin fragments with high affinity for lipoprotein lipase and inhibition of lipoprotein lipase binding to alpha 2-macroglobulin-receptor/low-density-lipoprotein-receptor-related protein by heparin fragments.
P50
Q24291185-EBCE8952-12C9-4C2A-82A0-439DB353FC71Q24293094-2D455C72-71DC-4D2D-B599-117962485BC5Q24307989-89078225-39C0-4F14-B565-F0E74FF89CEDQ24312692-728704D7-1ADB-4911-BF68-64B98BFA70D8Q24322095-BBD9AC9B-29D2-447B-8DCE-3E0DD7A192C8Q24329019-CD283084-000E-4E1D-B4A8-D73D94502861Q24532072-7EC5CF12-5EF1-4E5B-A53C-2647BC4BCD06Q24555085-FAA6D5E8-EA0A-4EA3-B807-43217CC857A9Q27332095-6037DFF5-913F-42A3-936B-2BA04E77D74EQ27675654-696ADD35-4F4A-45DD-A0C3-BC6227563C51Q28141555-2B915315-05C0-4D61-A787-80DFC9CA90E1Q28208178-DEE13F12-1B3E-4CE3-BE45-01AB888552E1Q28260073-21B6B900-FF30-43EA-9E0B-FB2F715AF928Q28273951-89E9CDB6-ECD4-400F-97E0-D991D36CC3D8Q28292378-CB03FF10-ED30-44B6-89FC-B795E162765BQ28298111-9637AC74-4E9D-4723-B3DF-EA62192C7DEEQ28302409-930AA646-F317-435F-95F3-46F9DD430E2EQ28510815-449F7EC2-20DD-4791-91A9-FC710FD210F2Q28513913-BEA81317-1DEE-498D-A18B-9B45B3AF02B5Q28588603-EA254C5C-BE08-4D3C-A071-310DAEDA4450Q30958722-2262AA5F-6C22-484F-A032-5F356901C58BQ30977865-F01DF429-8F41-40B4-9062-9251D4EB8B36Q33690344-90F13D9D-784F-445E-9FB5-92A9E540C737Q33772665-75905BF2-2709-4D15-85E7-EC183F836BB2Q34327500-F8197C2D-01F5-49A6-8081-593F8D4A9DCCQ34346014-AC59F5FD-10D9-4F01-A5E3-CF3B9D877EF6Q34403061-DD61795C-C58F-4B56-BC78-0E5FBBCCE352Q34448507-DD458618-206C-42B9-BCAE-4620B3B6CA20Q35145355-4A3BEB4C-F208-4292-B325-D6213EC4CDE1Q35210234-E873843F-56FC-4451-AE1F-FDF2523F787BQ35788270-38549A5A-CF54-4971-9A69-B1756AFD26A5Q36481872-5C8678B4-BB2D-438F-92AD-CDE6557EE4DBQ37323348-C4596E30-3DC1-43C5-82C3-8835099D27D1Q37814890-23AB3D46-2BAF-452F-8379-A755B4C500FFQ37896025-E33FB092-5632-44EA-86C6-8363036604E3Q38185068-0390D7B3-F918-4BD7-AECE-B578B72B150BQ38199412-3EF58F3D-E527-4D16-8E91-E9BA4C4D7F84Q38212601-F2219CE5-5A8A-4AF8-9801-90CD37D09077Q38290559-36FBF8D5-AB5D-44C2-A3D9-F0409A1AB9B1Q38297068-19825588-35DE-4B84-BD5B-FAF867AFFE6E
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Anders Nykjaer
@ast
Anders Nykjaer
@en
Anders Nykjaer
@es
Anders Nykjaer
@nl
Anders Nykjaer
@sl
type
label
Anders Nykjaer
@ast
Anders Nykjaer
@en
Anders Nykjaer
@es
Anders Nykjaer
@nl
Anders Nykjaer
@sl
altLabel
Anders Nykjær
@en
prefLabel
Anders Nykjaer
@ast
Anders Nykjaer
@en
Anders Nykjaer
@es
Anders Nykjaer
@nl
Anders Nykjaer
@sl
P106
P21
P31
P496
0000-0001-6422-6736