about
P185
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chipsUsing Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding SiteDouble Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled PeptidesRational methods for the selection of diverse screening compoundsA one-bead, one-stock solution approach to chemical genetics: part 2.Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform.Diversity-oriented synthesis; a spectrum of approaches and results.Diversity-oriented synthesis.Gemmacin B: bringing diversity back into focus.Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.Synthesis of unprecedented scaffold diversity.The discovery of antibacterial agents using diversity-oriented synthesis.Mastering the chemical language of bacteria.Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening.Quantitatively mapping cellular viscosity with detailed organelle information via a designed PET fluorescent probe.Diversity-oriented synthesis of macrocyclic peptidomimetics.Chemical genetics.Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae.PNA to DNA to microarray decoding facilitates ligand discovery.Diversity-oriented synthesis: producing chemical tools for dissecting biology.A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?Multifunctional supramolecular polymer networks as next-generation consolidants for archaeological wood conservation.A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.How diverse are diversity assessment methods? A comparative analysis and benchmarking of molecular descriptor space.Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium.Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy.Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis.A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffoldsCommunications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex MacrocyclesPartially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.
P50
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P50
description
organic chemist
@en
scheikundige
@nl
عالم كيمياء عضوية
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name
David R Spring
@es
David R Spring
@nl
David R Spring
@sl
David R. Spring
@en
David R. Spring
@sq
ديفيد ر. سبرينغ
@ar
type
label
David R Spring
@es
David R Spring
@nl
David R Spring
@sl
David R. Spring
@en
David R. Spring
@sq
ديفيد ر. سبرينغ
@ar
altLabel
David Spring
@en
prefLabel
David R Spring
@es
David R Spring
@nl
David R Spring
@sl
David R. Spring
@en
David R. Spring
@sq
ديفيد ر. سبرينغ
@ar
P1053
K-2283-2016
P184
P21
P31
P3829
P496
0000-0001-7355-2824