Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.
about
Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsDiversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interactionParallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization.A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators.Exploration of Scaffolds from Natural Products with Antiplasmodial Activities, Currently Registered Antimalarial Drugs and Public Malarial Screen Data.Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity.Diversity-oriented synthesis of macrocyclic peptidomimetics.Route to three-dimensional fragments using diversity-oriented synthesis.Role of natural product diversity in chemical biology.Recent trends and observations in the design of high-quality screening collections.Chemical genetics.Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and β-amino alcohols.Towards the systematic exploration of chemical space.Remodelling of the natural product fumagillol employing a reaction discovery approachNatural product synthesis at the interface of chemistry and biology.Diversity-oriented synthesis: producing chemical tools for dissecting biology.A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.Exploring chemical diversity via a modular reaction pairing strategyOvercoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products.Macrocyclic drugs and synthetic methodologies toward macrocyclesIdentification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)Electrophile induced branching cascade: a powerful approach to access various molecular scaffolds and their exploration as novel anti-mycobacterial agents.High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.Network measures for chemical library design.Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy.Diversity-oriented synthesis as a tool for chemical genetics.A unified lead-oriented synthesis of over fifty molecular scaffolds.A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffoldsTargeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Generation of N-Heterocycles via Tandem Reactions of N '-(2-Alkynylbenzylidene)hydrazides.Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.Hierarchy and extremes in selections from pools of randomized proteinsEfficient access to sp3-rich tricyclic amine scaffolds through Diels-Alder reactions of azide-containing silyloxydienes.A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex MacrocyclesIdentification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings.
P2860
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P2860
Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Diversity-oriented synthesis a ...... ically active small molecules.
@ast
Diversity-oriented synthesis a ...... ically active small molecules.
@en
type
label
Diversity-oriented synthesis a ...... ically active small molecules.
@ast
Diversity-oriented synthesis a ...... ically active small molecules.
@en
prefLabel
Diversity-oriented synthesis a ...... ically active small molecules.
@ast
Diversity-oriented synthesis a ...... ically active small molecules.
@en
P2860
P356
P1476
Diversity-oriented synthesis a ...... ically active small molecules.
@en
P2093
Albert Isidro-Llobet
Warren R J D Galloway
P2860
P2888
P356
10.1038/NCOMMS1081
P407
P577
2010-09-21T00:00:00Z
P5875
P6179
1031283139