about
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodentsGenetic disorders and molecular mechanisms in cholestatic liver disease--a clinical approach.Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.Molecular mechanisms of cholestasis.Clinical hepatotoxicity. Regulation and treatment with inducers of transport and cofactors.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.New molecular insights into the mechanisms of cholestasis.Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis.New insights into autoimmune cholangitis through animal models.Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease.Nuclear receptors in liver disease.Targeting nuclear bile acid receptors for liver disease.Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis.Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis.Differential effects of norUDCA and UDCA in obstructive cholestasis in miceGrowth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver.Induction of short heterodimer partner 1 precedes downregulation of Ntcp in bile duct-ligated mice.Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles.Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice.Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine.Sudden hearing loss in patients with chronic hepatitis C treated with pegylated interferon/ribavirin.Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.Oncosis represents the main type of cell death in mouse models of cholestasis.CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans.Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.Extracorporeal albumin dialysis in a patient with primary sclerosing cholangitis: effect on pruritus and bile acid profile.Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans.Alterations of canalicular ATP-binding cassette transporter expression in drug-induced liver injury.Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.Hepatobiliary transporter expression in human hepatocellular carcinoma.Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing CholangitisAbnormal hepatic sinusoidal bile acid transport: new insights into the pathogenesis of cholestasis?
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Gernot Zollner
@ast
Gernot Zollner
@en
Gernot Zollner
@es
Gernot Zollner
@nl
Gernot Zollner
@sl
type
label
Gernot Zollner
@ast
Gernot Zollner
@en
Gernot Zollner
@es
Gernot Zollner
@nl
Gernot Zollner
@sl
prefLabel
Gernot Zollner
@ast
Gernot Zollner
@en
Gernot Zollner
@es
Gernot Zollner
@nl
Gernot Zollner
@sl
P106
P21
P31
P496
0000-0002-8117-6061