Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
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Bile acid transporters in health and diseaseBile acid transportersUpregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodentsObstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2Clinical application of transcriptional activators of bile salt transporters.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease.Foxa2-dependent hepatic gene regulatory networks depend on physiological stateHepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.Deficiency of Capicua disrupts bile acid homeostasis.Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expressionBile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity.Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice.Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression.Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine.Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet.Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.GW4064 attenuates lipopolysaccharide‑induced hepatic inflammation and apoptosis through inhibition of the Toll‑like receptor 4‑mediated p38 mitogen‑activated protein kinase signaling pathway in mice.
P2860
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P2860
Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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name
Role of nuclear receptors and ...... ry obstruction in mouse liver.
@en
Role of nuclear receptors and ...... ry obstruction in mouse liver.
@nl
type
label
Role of nuclear receptors and ...... ry obstruction in mouse liver.
@en
Role of nuclear receptors and ...... ry obstruction in mouse liver.
@nl
prefLabel
Role of nuclear receptors and ...... ry obstruction in mouse liver.
@en
Role of nuclear receptors and ...... ry obstruction in mouse liver.
@nl
P2093
P2860
P50
P356
P1476
Role of nuclear receptors and ...... ry obstruction in mouse liver.
@en
P2093
Andrea Fuchsbichler
Andreas Geier
Arthur Kaser
Dagmar Silbert
Helmut Denk
Herbert Tilg
Judith Gumhold
Martin Wagner
Michael Trauner
P2860
P304
P356
10.1152/AJPGI.00319.2004
P577
2005-07-07T00:00:00Z